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Amplification of human interneuron progenitors promotes brain tumors and neurological defects.
Eichmüller OL, Corsini NS, Vértesy Á, Morassut I, Scholl T, Gruber VE, Peer AM, Chu J, Novatchkova M, Hainfellner JA, Paredes MF, Feucht M, Knoblich JA. Eichmüller OL, et al. Among authors: knoblich ja. Science. 2022 Jan 28;375(6579):eabf5546. doi: 10.1126/science.abf5546. Epub 2022 Jan 28. Science. 2022. PMID: 35084981 Free PMC article.
The HUSH complex controls brain architecture and protocadherin fidelity.
Hagelkruys A, Horrer M, Taubenschmid-Stowers J, Kavirayani A, Novatchkova M, Orthofer M, Pai TP, Cikes D, Zhuk S, Balmaña M, Esk C, Koglgruber R, Moeseneder P, Lazovic J, Zopf LM, Cronin SJF, Elling U, Knoblich JA, Penninger JM. Hagelkruys A, et al. Among authors: knoblich ja. Sci Adv. 2022 Nov 4;8(44):eabo7247. doi: 10.1126/sciadv.abo7247. Epub 2022 Nov 4. Sci Adv. 2022. PMID: 36332029 Free PMC article.
In vitro modeling of the human dopaminergic system using spatially arranged ventral midbrain-striatum-cortex assembloids.
Reumann D, Krauditsch C, Novatchkova M, Sozzi E, Wong SN, Zabolocki M, Priouret M, Doleschall B, Ritzau-Reid KI, Piber M, Morassut I, Fieseler C, Fiorenzano A, Stevens MM, Zimmer M, Bardy C, Parmar M, Knoblich JA. Reumann D, et al. Among authors: knoblich ja. Nat Methods. 2023 Dec;20(12):2034-2047. doi: 10.1038/s41592-023-02080-x. Epub 2023 Dec 5. Nat Methods. 2023. PMID: 38052989 Free PMC article.
ARID1B controls transcriptional programs of axon projection in an organoid model of the human corpus callosum.
Martins-Costa C, Wiegers A, Pham VA, Sidhaye J, Doleschall B, Novatchkova M, Lendl T, Piber M, Peer A, Möseneder P, Stuempflen M, Chow SYA, Seidl R, Prayer D, Höftberger R, Kasprian G, Ikeuchi Y, Corsini NS, Knoblich JA. Martins-Costa C, et al. Among authors: knoblich ja. Cell Stem Cell. 2024 May 6:S1934-5909(24)00141-3. doi: 10.1016/j.stem.2024.04.014. Online ahead of print. Cell Stem Cell. 2024. PMID: 38718796 Free article.
A single allele of Hdac2 but not Hdac1 is sufficient for normal mouse brain development in the absence of its paralog.
Hagelkruys A, Lagger S, Krahmer J, Leopoldi A, Artaker M, Pusch O, Zezula J, Weissmann S, Xie Y, Schöfer C, Schlederer M, Brosch G, Matthias P, Selfridge J, Lassmann H, Knoblich JA, Seiser C. Hagelkruys A, et al. Among authors: knoblich ja. Development. 2014 Feb;141(3):604-616. doi: 10.1242/dev.100487. Development. 2014. PMID: 24449838 Free PMC article.
154 results