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HER2 Mediates PSMA/mGluR1-Driven Resistance to the DS-7423 Dual PI3K/mTOR Inhibitor in PTEN Wild-type Prostate Cancer Models.
Gómez V, Galazi M, Weitsman G, Monypenny J, Al-Salemee F, Barber PR, Ng K, Beatson R, Szokol B, Orfi L, Mullen G, Vanhaesebroeck B, Chowdhury S, Leung HY, Ng T. Gómez V, et al. Among authors: vanhaesebroeck b. Mol Cancer Ther. 2022 Apr 1;21(4):667-676. doi: 10.1158/1535-7163.MCT-21-0320. Mol Cancer Ther. 2022. PMID: 35086953 Free PMC article.
Plasma Metabolomic Changes following PI3K Inhibition as Pharmacodynamic Biomarkers: Preclinical Discovery to Phase I Trial Evaluation.
Ang JE, Pandher R, Ang JC, Asad YJ, Henley AT, Valenti M, Box G, de Haven Brandon A, Baird RD, Friedman L, Derynck M, Vanhaesebroeck B, Eccles SA, Kaye SB, Workman P, de Bono JS, Raynaud FI. Ang JE, et al. Among authors: vanhaesebroeck b. Mol Cancer Ther. 2016 Jun;15(6):1412-24. doi: 10.1158/1535-7163.MCT-15-0815. Epub 2016 Apr 5. Mol Cancer Ther. 2016. PMID: 27048952 Free PMC article. Clinical Trial.
Precision Targeting of Mutant PI3Kα.
Gong GQ, Vanhaesebroeck B. Gong GQ, et al. Among authors: vanhaesebroeck b. Cancer Discov. 2024 Feb 8;14(2):204-207. doi: 10.1158/2159-8290.CD-23-1392. Cancer Discov. 2024. PMID: 38327193
PI3K regulatory subunits lose control in cancer.
Berenjeno IM, Vanhaesebroeck B. Berenjeno IM, et al. Among authors: vanhaesebroeck b. Cancer Cell. 2009 Dec 8;16(6):449-50. doi: 10.1016/j.ccr.2009.11.017. Cancer Cell. 2009. PMID: 19962660 Free article.
217 results