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A single-cell transcriptional gradient in human cutaneous memory T cells restricts Th17/Tc17 identity.
Cook CP, Taylor M, Liu Y, Schmidt R, Sedgewick A, Kim E, Hailer A, North JP, Harirchian P, Wang H, Kashem SW, Shou Y, McCalmont TC, Benz SC, Choi J, Purdom E, Marson A, Ramos SBV, Cheng JB, Cho RJ. Cook CP, et al. Among authors: schmidt r. Cell Rep Med. 2022 Aug 16;3(8):100715. doi: 10.1016/j.xcrm.2022.100715. Cell Rep Med. 2022. PMID: 35977472 Free PMC article.
Base-editing mutagenesis maps alleles to tune human T cell functions.
Schmidt R, Ward CC, Dajani R, Armour-Garb Z, Ota M, Allain V, Hernandez R, Layeghi M, Xing G, Goudy L, Dorovskyi D, Wang C, Chen YY, Ye CJ, Shy BR, Gilbert LA, Eyquem J, Pritchard JK, Dodgson SE, Marson A. Schmidt R, et al. Nature. 2024 Jan;625(7996):805-812. doi: 10.1038/s41586-023-06835-6. Epub 2023 Dec 13. Nature. 2024. PMID: 38093011
Improving prime editing with an endogenous small RNA-binding protein.
Yan J, Oyler-Castrillo P, Ravisankar P, Ward CC, Levesque S, Jing Y, Simpson D, Zhao A, Li H, Yan W, Goudy L, Schmidt R, Solley SC, Gilbert LA, Chan MM, Bauer DE, Marson A, Parsons LR, Adamson B. Yan J, et al. Among authors: schmidt r. Nature. 2024 Apr;628(8008):639-647. doi: 10.1038/s41586-024-07259-6. Epub 2024 Apr 3. Nature. 2024. PMID: 38570691 Free PMC article.
Systematic decoding of cis gene regulation defines context-dependent control of the multi-gene costimulatory receptor locus in human T cells.
Mowery CT, Freimer JW, Chen Z, Casaní-Galdón S, Umhoefer JM, Arce MM, Gjoni K, Daniel B, Sandor K, Gowen BG, Nguyen V, Simeonov DR, Garrido CM, Curie GL, Schmidt R, Steinhart Z, Satpathy AT, Pollard KS, Corn JE, Bernstein BE, Ye CJ, Marson A. Mowery CT, et al. Among authors: schmidt r. Nat Genet. 2024 May 29. doi: 10.1038/s41588-024-01743-5. Online ahead of print. Nat Genet. 2024. PMID: 38811842
Chloroquine inhibits human CD4+ T-cell activation by AP-1 signaling modulation.
Schmidt RL, Jutz S, Goldhahn K, Witzeneder N, Gerner MC, Trapin D, Greiner G, Hoermann G, Steiner G, Pickl WF, Burgmann H, Steinberger P, Ratzinger F, Schmetterer KG. Schmidt RL, et al. Sci Rep. 2017 Feb 7;7:42191. doi: 10.1038/srep42191. Sci Rep. 2017. PMID: 28169350 Free PMC article.
Overexpression of PDE4A Acts as Checkpoint Inhibitor Against cAMP-Mediated Immunosuppression in vitro.
Schmetterer KG, Goldhahn K, Ziegler LS, Gerner MC, Schmidt RLJ, Themanns M, Zebedin-Brandl E, Trapin D, Leitner J, Pickl WF, Steinberger P, Schwarzinger I, Marculescu R. Schmetterer KG, et al. Among authors: schmidt rlj. Front Immunol. 2019 Jul 30;10:1790. doi: 10.3389/fimmu.2019.01790. eCollection 2019. Front Immunol. 2019. PMID: 31417563 Free PMC article.
6,151 results