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The IGFBP3/TMEM219 pathway regulates beta cell homeostasis.
D'Addio F, Maestroni A, Assi E, Ben Nasr M, Amabile G, Usuelli V, Loretelli C, Bertuzzi F, Antonioli B, Cardarelli F, El Essawy B, Solini A, Gerling IC, Bianchi C, Becchi G, Mazzucchelli S, Corradi D, Fadini GP, Foschi D, Markmann JF, Orsi E, Škrha J Jr, Camboni MG, Abdi R, James Shapiro AM, Folli F, Ludvigsson J, Del Prato S, Zuccotti G, Fiorina P. D'Addio F, et al. Among authors: markmann jf. Nat Commun. 2022 Feb 3;13(1):684. doi: 10.1038/s41467-022-28360-2. Nat Commun. 2022. PMID: 35115561 Free PMC article.
IL-21 is an antitolerogenic cytokine of the late-phase alloimmune response.
Petrelli A, Carvello M, Vergani A, Lee KM, Tezza S, Du M, Kleffel S, Chengwen L, Mfarrej BG, Hwu P, Secchi A, Leonard WJ, Young D, Sayegh MH, Markmann JF, Zajac AJ, Fiorina P. Petrelli A, et al. Among authors: markmann jf. Diabetes. 2011 Dec;60(12):3223-34. doi: 10.2337/db11-0880. Epub 2011 Oct 19. Diabetes. 2011. PMID: 22013017 Free PMC article.
B-cell depletion improves islet allograft survival with anti-CD45RB.
Lee KM, Yeh H, Zhao G, Wei L, O'Connor M, Stott RT, Soohoo J, Dunussi K, Fiorina P, Deng S, Markmann JF, Kim JI. Lee KM, et al. Among authors: markmann jf. Cell Transplant. 2014 Jan;23(1):51-8. doi: 10.3727/096368912X658962. Epub 2012 Nov 27. Cell Transplant. 2014. PMID: 23192154 Free PMC article.
TIM4 Regulates the Anti-Islet Th2 Alloimmune Response.
Vergani A, Gatti F, Lee KM, D'Addio F, Tezza S, Chin M, Bassi R, Tian Z, Wu E, Maffi P, Ben Nasr M, Kim JI, Secchi A, Markmann JF, Rothstein DM, Turka LA, Sayegh MH, Fiorina P. Vergani A, et al. Among authors: markmann jf. Cell Transplant. 2015;24(8):1599-1614. doi: 10.3727/096368914X678571. Epub 2014 Mar 7. Cell Transplant. 2015. PMID: 24612609 Free PMC article.
Co-transplantation of autologous MSCs delays islet allograft rejection and generates a local immunoprivileged site.
Ben Nasr M, Vergani A, Avruch J, Liu L, Kefaloyianni E, D'Addio F, Tezza S, Corradi D, Bassi R, Valderrama-Vasquez A, Usuelli V, Kim J, Azzi J, El Essawy B, Markmann J, Abdi R, Fiorina P. Ben Nasr M, et al. Acta Diabetol. 2015 Oct;52(5):917-27. doi: 10.1007/s00592-015-0735-y. Epub 2015 Mar 27. Acta Diabetol. 2015. PMID: 25808641 Free PMC article.
PD-L1 genetic overexpression or pharmacological restoration in hematopoietic stem and progenitor cells reverses autoimmune diabetes.
Ben Nasr M, Tezza S, D'Addio F, Mameli C, Usuelli V, Maestroni A, Corradi D, Belletti S, Albarello L, Becchi G, Fadini GP, Schuetz C, Markmann J, Wasserfall C, Zon L, Zuccotti GV, Fiorina P. Ben Nasr M, et al. Sci Transl Med. 2017 Nov 15;9(416):eaam7543. doi: 10.1126/scitranslmed.aam7543. Sci Transl Med. 2017. PMID: 29141886 Free PMC article.
Regulatory B Cells in Autoimmune Diabetes.
Ben Nasr M, Usuelli V, Seelam AJ, D'Addio F, Abdi R, Markmann JF, Fiorina P. Ben Nasr M, et al. Among authors: markmann jf. J Immunol. 2021 Mar 15;206(6):1117-1125. doi: 10.4049/jimmunol.2001127. J Immunol. 2021. PMID: 33685919 Review.
374 results