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Base editing sensor libraries for high-throughput engineering and functional analysis of cancer-associated single nucleotide variants.
Nat Biotechnol. 2022 Jun;40(6):862-873. doi: 10.1038/s41587-021-01172-3. Epub 2022 Feb 14.
Nat Biotechnol. 2022.
PMID: 35165384
Free PMC article.
Senescence Rewires Microenvironment Sensing to Facilitate Antitumor Immunity.
Chen HA, Ho YJ, Mezzadra R, Adrover JM, Smolkin R, Zhu C, Woess K, Bernstein N, Schmitt G, Fong L, Luan W, Wuest A, Tian S, Li X, Broderick C, Hendrickson RC, Egeblad M, Chen Z, Alonso-Curbelo D, Lowe SW.
Chen HA, et al. Among authors: wuest a.
Cancer Discov. 2023 Feb 6;13(2):432-453. doi: 10.1158/2159-8290.CD-22-0528.
Cancer Discov. 2023.
PMID: 36302222
Free PMC article.
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MACHETE identifies interferon-encompassing chromosome 9p21.3 deletions as mediators of immune evasion and metastasis.
Barriga FM, Tsanov KM, Ho YJ, Sohail N, Zhang A, Baslan T, Wuest AN, Del Priore I, Meškauskaitė B, Livshits G, Alonso-Curbelo D, Simon J, Chaves-Perez A, Bar-Sagi D, Iacobuzio-Donahue CA, Notta F, Chaligne R, Sharma R, Pe'er D, Lowe SW.
Barriga FM, et al. Among authors: wuest an.
Nat Cancer. 2022 Nov;3(11):1367-1385. doi: 10.1038/s43018-022-00443-5. Epub 2022 Nov 7.
Nat Cancer. 2022.
PMID: 36344707
Free PMC article.
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Epigenetic plasticity cooperates with cell-cell interactions to direct pancreatic tumorigenesis.
Burdziak C, Alonso-Curbelo D, Walle T, Reyes J, Barriga FM, Haviv D, Xie Y, Zhao Z, Zhao CJ, Chen HA, Chaudhary O, Masilionis I, Choo ZN, Gao V, Luan W, Wuest A, Ho YJ, Wei Y, Quail DF, Koche R, Mazutis L, Chaligné R, Nawy T, Lowe SW, Pe'er D.
Burdziak C, et al. Among authors: wuest a.
Science. 2023 May 12;380(6645):eadd5327. doi: 10.1126/science.add5327. Epub 2023 May 12.
Science. 2023.
PMID: 37167403
Free PMC article.
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Generation of precision preclinical cancer models using regulated in vivo base editing.
Katti A, Vega-Pérez A, Foronda M, Zimmerman J, Zafra MP, Granowsky E, Goswami S, Gardner EE, Diaz BJ, Simon JM, Wuest A, Luan W, Fernandez MTC, Kadina AP, Walker JA 2nd, Holden K, Lowe SW, Sánchez Rivera FJ, Dow LE.
Katti A, et al.
Nat Biotechnol. 2024 Mar;42(3):437-447. doi: 10.1038/s41587-023-01900-x. Epub 2023 Aug 10.
Nat Biotechnol. 2024.
PMID: 37563300
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Somatic mouse models of gastric cancer reveal genotype-specific features of metastatic disease.
Leibold J, Tsanov KM, Amor C, Ho YJ, Sánchez-Rivera FJ, Feucht J, Baslan T, Chen HA, Tian S, Simon J, Wuest A, Wilkinson JE, Lowe SW.
Leibold J, et al. Among authors: wuest a.
Nat Cancer. 2024 Feb;5(2):315-329. doi: 10.1038/s43018-023-00686-w. Epub 2024 Jan 4.
Nat Cancer. 2024.
PMID: 38177458
Free PMC article.
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High-throughput evaluation of genetic variants with prime editing sensor libraries.
Gould SI, Wuest AN, Dong K, Johnson GA, Hsu A, Narendra VK, Atwa O, Levine SS, Liu DR, Sánchez Rivera FJ.
Gould SI, et al. Among authors: wuest an.
Nat Biotechnol. 2024 Mar 12. doi: 10.1038/s41587-024-02172-9. Online ahead of print.
Nat Biotechnol. 2024.
PMID: 38472508
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Metastatic site influences driver gene function in pancreatic cancer.
Tsanov KM, Barriga FM, Ho YJ, Alonso-Curbelo D, Livshits G, Koche RP, Baslan T, Simon J, Tian S, Wuest AN, Luan W, Wilkinson JE, Masilionis I, Dimitrova N, Iacobuzio-Donahue CA, Chaligné R, Pe'er D, Massagué J, Lowe SW.
Tsanov KM, et al. Among authors: wuest an.
bioRxiv [Preprint]. 2024 Mar 18:2024.03.17.585402. doi: 10.1101/2024.03.17.585402.
bioRxiv. 2024.
PMID: 38562717
Free PMC article.
Preprint.
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