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Integrated Genomic Analysis Identifies UBTF Tandem Duplications as a Recurrent Lesion in Pediatric Acute Myeloid Leukemia.
Umeda M, Ma J, Huang BJ, Hagiwara K, Westover T, Abdelhamed S, Barajas JM, Thomas ME, Walsh MP, Song G, Tian L, Liu Y, Chen X, Kolekar P, Tran Q, Foy SG, Maciaszek JL, Kleist AB, Leonti AR, Ju B, Easton J, Wu H, Valentine V, Valentine MB, Liu YC, Ries RE, Smith JL, Parganas E, Iacobucci I, Hiltenbrand R, Miller J, Myers JR, Rampersaud E, Rahbarinia D, Rusch M, Wu G, Inaba H, Wang YC, Alonzo TA, Downing JR, Mullighan CG, Pounds S, Babu MM, Zhang J, Rubnitz JE, Meshinchi S, Ma X, Klco JM. Umeda M, et al. Among authors: thomas me. Blood Cancer Discov. 2022 May 5;3(3):194-207. doi: 10.1158/2643-3230.BCD-21-0160. Blood Cancer Discov. 2022. PMID: 35176137 Free PMC article.
Mutant Samd9l expression impairs hematopoiesis and induces bone marrow failure in mice.
Abdelhamed S, Thomas ME 3rd, Westover T, Umeda M, Xiong E, Rolle C, Walsh MP, Wu H, Schwartz JR, Valentine V, Valentine M, Pounds S, Ma J, Janke LJ, Klco JM. Abdelhamed S, et al. Among authors: thomas me 3rd. J Clin Invest. 2022 Nov 1;132(21):e158869. doi: 10.1172/JCI158869. J Clin Invest. 2022. PMID: 36074606 Free PMC article.
Acute myeloid leukemias with UBTF tandem duplications are sensitive to menin inhibitors.
Barajas JM, Rasouli M, Umeda M, Hiltenbrand R, Abdelhamed S, Mohnani R, Arthur B, Westover T, Thomas ME 3rd, Ashtiani M, Janke LJ, Xu B, Chang TC, Rosikiewicz W, Xiong E, Rolle C, Low J, Krishan R, Song G, Walsh MP, Ma J, Rubnitz JE, Iacobucci I, Chen T, Krippner-Heidenreich A, Zwaan CM, Heidenreich O, Klco JM. Barajas JM, et al. Among authors: thomas me 3rd. Blood. 2024 Feb 15;143(7):619-630. doi: 10.1182/blood.2023021359. Blood. 2024. PMID: 37890156 Free PMC article.
UBTF Tandem Duplications in Pediatric MDS and AML: Implications for Clinical Screening and Diagnosis.
Barajas JM, Umeda M, Contreras L, Khanlari M, Westover T, Walsh MP, Xiong E, Yang C, Otero B, Arribas-Layton M, Abdelhamed S, Song G, Ma X, Thomas ME, Ma J, Klco JM. Barajas JM, et al. Among authors: thomas me. medRxiv [Preprint]. 2023 Nov 13:2023.11.13.23298320. doi: 10.1101/2023.11.13.23298320. medRxiv. 2023. PMID: 38014207 Free PMC article. Updated. Preprint.
Selective CK1α degraders exert antiproliferative activity against a broad range of human cancer cell lines.
Nishiguchi G, Mascibroda LG, Young SM, Caine EA, Abdelhamed S, Kooijman JJ, Miller DJ, Das S, McGowan K, Mayasundari A, Shi Z, Barajas JM, Hiltenbrand R, Aggarwal A, Chang Y, Mishra V, Narina S, Thomas M, Loughran AJ, Kalathur R, Yu K, Zhou S, Wang X, High AA, Peng J, Pruett-Miller SM, Daniels DL, Urh M, Shelat AA, Mullighan CG, Riching KM, Zaman GJR, Fischer M, Klco JM, Rankovic Z. Nishiguchi G, et al. Nat Commun. 2024 Jan 16;15(1):482. doi: 10.1038/s41467-024-44698-1. Nat Commun. 2024. PMID: 38228616 Free PMC article.
147 results