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Functionally selective signaling and broad metabolic benefits by novel insulin receptor partial agonists.
Wu M, Carballo-Jane E, Zhou H, Zafian P, Dai G, Liu M, Lao J, Kelly T, Shao D, Gorski J, Pissarnitski D, Kekec A, Chen Y, Previs SF, Scapin G, Gomez-Llorente Y, Hollingsworth SA, Yan L, Feng D, Huo P, Walford G, Erion MD, Kelley DE, Lin S, Mu J. Wu M, et al. Among authors: chen y. Nat Commun. 2022 Feb 17;13(1):942. doi: 10.1038/s41467-022-28561-9. Nat Commun. 2022. PMID: 35177603 Free PMC article.
Phenotyping of adipose, liver, and skeletal muscle insulin resistance and response to pioglitazone in spontaneously obese rhesus monkeys.
Shang J, Previs SF, Conarello S, Chng K, Zhu Y, Souza SC, Staup M, Chen Y, Xie D, Zycband E, Schlessinger K, Johnson VP, Arreaza G, Liu F, Levitan D, Wang L, van Heek M, Erion M, Wang Y, Kelley DE. Shang J, et al. Among authors: chen y. Am J Physiol Endocrinol Metab. 2017 Apr 1;312(4):E235-E243. doi: 10.1152/ajpendo.00398.2016. Epub 2017 Jan 31. Am J Physiol Endocrinol Metab. 2017. PMID: 28143858 Free article.
GPR120 suppresses adipose tissue lipolysis and synergizes with GPR40 in antidiabetic efficacy.
Satapati S, Qian Y, Wu MS, Petrov A, Dai G, Wang SP, Zhu Y, Shen X, Muise ES, Chen Y, Zycband E, Weinglass A, Di Salvo J, Debenham JS, Cox JM, Lan P, Shah V, Previs SF, Erion M, Kelley DE, Wang L, Howard AD, Shang J. Satapati S, et al. Among authors: chen y. J Lipid Res. 2017 Aug;58(8):1561-1578. doi: 10.1194/jlr.M075044. Epub 2017 Jun 5. J Lipid Res. 2017. PMID: 28583918 Free PMC article.
Spatial and temporal studies of metabolic activity: contrasting biochemical kinetics in tissues and pathways during fasted and fed states.
Daurio NA, Wang Y, Chen Y, Zhou H, Carballo-Jane E, Mane J, Rodriguez CG, Zafian P, Houghton A, Addona G, McLaren DG, Zhang R, Shyong BJ, Bateman K, Downes DP, Webb M, Kelley DE, Previs SF. Daurio NA, et al. Among authors: chen y. Am J Physiol Endocrinol Metab. 2019 Jun 1;316(6):E1105-E1117. doi: 10.1152/ajpendo.00459.2018. Epub 2019 Mar 26. Am J Physiol Endocrinol Metab. 2019. PMID: 30912961 Free article.
Quantifying rates of glucose production in vivo following an intraperitoneal tracer bolus.
Wang SP, Zhou D, Yao Z, Satapati S, Chen Y, Daurio NA, Petrov A, Shen X, Metzger D, Yin W, Nawrocki AR, Eiermann GJ, Hwa J, Fancourt C, Miller C, Herath K, Roddy TP, Slipetz D, Erion MD, Previs SF, Kelley DE. Wang SP, et al. Among authors: chen y. Am J Physiol Endocrinol Metab. 2016 Dec 1;311(6):E911-E921. doi: 10.1152/ajpendo.00182.2016. Epub 2016 Sep 20. Am J Physiol Endocrinol Metab. 2016. PMID: 27651111 Free article.
Enhancing Studies of Pharmacodynamic Mechanisms via Measurements of Metabolic Flux: Fundamental Concepts and Guiding Principles for Using Stable Isotope Tracers.
Daurio NA, Wang SP, Chen Y, Zhou H, McLaren DG, Roddy TP, Johns DG, Milot D, Kasumov T, Erion MD, Kelley DE, Previs SF. Daurio NA, et al. Among authors: chen y. J Pharmacol Exp Ther. 2017 Oct;363(1):80-91. doi: 10.1124/jpet.117.241091. Epub 2017 Jul 19. J Pharmacol Exp Ther. 2017. PMID: 28724692 Review.
Targeting a ceramide double bond improves insulin resistance and hepatic steatosis.
Chaurasia B, Tippetts TS, Mayoral Monibas R, Liu J, Li Y, Wang L, Wilkerson JL, Sweeney CR, Pereira RF, Sumida DH, Maschek JA, Cox JE, Kaddai V, Lancaster GI, Siddique MM, Poss A, Pearson M, Satapati S, Zhou H, McLaren DG, Previs SF, Chen Y, Qian Y, Petrov A, Wu M, Shen X, Yao J, Nunes CN, Howard AD, Wang L, Erion MD, Rutter J, Holland WL, Kelley DE, Summers SA. Chaurasia B, et al. Among authors: chen y. Science. 2019 Jul 26;365(6451):386-392. doi: 10.1126/science.aav3722. Epub 2019 Jul 4. Science. 2019. PMID: 31273070 Free PMC article.
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