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Proteomic profiling reveals CDK6 upregulation as a targetable resistance mechanism for lenalidomide in multiple myeloma.
Ng YLD, Ramberger E, Bohl SR, Dolnik A, Steinebach C, Conrad T, Müller S, Popp O, Kull M, Haji M, Gütschow M, Döhner H, Walther W, Keller U, Bullinger L, Mertins P, Krönke J. Ng YLD, et al. Among authors: walther w. Nat Commun. 2022 Feb 23;13(1):1009. doi: 10.1038/s41467-022-28515-1. Nat Commun. 2022. PMID: 35197447 Free PMC article.
Patient-derived xenograft (PDX) models of colorectal carcinoma (CRC) as a platform for chemosensitivity and biomarker analysis in personalized medicine.
Rivera M, Fichtner I, Wulf-Goldenberg A, Sers C, Merk J, Patone G, Alp KM, Kanashova T, Mertins P, Hoffmann J, Stein U, Walther W. Rivera M, et al. Among authors: walther w. Neoplasia. 2021 Jan;23(1):21-35. doi: 10.1016/j.neo.2020.11.005. Epub 2020 Nov 16. Neoplasia. 2021. PMID: 33212364 Free PMC article.
The newly identified MEK1 tyrosine phosphorylation target MACC1 is druggable by approved MEK1 inhibitors to restrict colorectal cancer metastasis.
Kobelt D, Perez-Hernandez D, Fleuter C, Dahlmann M, Zincke F, Smith J, Migotti R, Popp O, Burock S, Walther W, Dittmar G, Mertins P, Stein U. Kobelt D, et al. Among authors: walther w. Oncogene. 2021 Aug;40(34):5286-5301. doi: 10.1038/s41388-021-01917-z. Epub 2021 Jul 10. Oncogene. 2021. PMID: 34247190 Free PMC article.
Conventional amphotericin B elicits markers of immunogenic cell death on leukemic blasts, mediates immunostimulatory effects on phagocytic cells, and synergizes with PD-L1 blockade.
Kofla G, Radecke C, Frentsch M, Walther W, Stintzing S, Riess H, Bullinger L, Na IK. Kofla G, et al. Among authors: walther w. Oncoimmunology. 2022 Apr 25;11(1):2068109. doi: 10.1080/2162402X.2022.2068109. eCollection 2022. Oncoimmunology. 2022. PMID: 35496500 Free PMC article.
Activation of gp130 signaling in T cells drives TH17-mediated multi-organ autoimmunity.
Baumgartner F, Bamopoulos SA, Faletti L, Hsiao HJ, Holz M, Gonzalez-Menendez I, Solé-Boldo L, Horne A, Gosavi S, Özerdem C, Singh N, Liebig S, Ramamoorthy S, Lehmann M, Demel U, Kühl AA, Wartewig T, Ruland J, Wunderlich FT, Schick M, Walther W, Rose-John S, Haas S, Quintanilla-Martinez L, Feske S, Ehl S, Glauben R, Keller U. Baumgartner F, et al. Among authors: walther w. Sci Signal. 2024 Feb 20;17(824):eadc9662. doi: 10.1126/scisignal.adc9662. Epub 2024 Feb 20. Sci Signal. 2024. PMID: 38377177
Establishment and Thorough Characterization of Xenograft (PDX) Models Derived from Patients with Pancreatic Cancer for Molecular Analyses and Chemosensitivity Testing.
Behrens D, Pfohl U, Conrad T, Becker M, Brzezicha B, Büttner B, Wagner S, Hallas C, Lawlor R, Khazak V, Linnebacher M, Wartmann T, Fichtner I, Hoffmann J, Dahlmann M, Walther W. Behrens D, et al. Among authors: walther w. Cancers (Basel). 2023 Dec 8;15(24):5753. doi: 10.3390/cancers15245753. Cancers (Basel). 2023. PMID: 38136299 Free PMC article.
Identification of Y-box binding protein 1 as a core regulator of MEK/ERK pathway-dependent gene signatures in colorectal cancer cells.
Jürchott K, Kuban RJ, Krech T, Blüthgen N, Stein U, Walther W, Friese C, Kiełbasa SM, Ungethüm U, Lund P, Knösel T, Kemmner W, Morkel M, Fritzmann J, Schlag PM, Birchmeier W, Krueger T, Sperling S, Sers C, Royer HD, Herzel H, Schäfer R. Jürchott K, et al. Among authors: walther w. PLoS Genet. 2010 Dec 2;6(12):e1001231. doi: 10.1371/journal.pgen.1001231. PLoS Genet. 2010. PMID: 21170361 Free PMC article.
224 results