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Effective drug combinations in breast, colon and pancreatic cancer cells.
Nature. 2022 Mar;603(7899):166-173. doi: 10.1038/s41586-022-04437-2. Epub 2022 Feb 23.
Nature. 2022.
PMID: 35197630
Free PMC article.
Primary and acquired resistance to EGFR-targeted therapies in colorectal cancer: impact on future treatment strategies.
Leto SM, Trusolino L.
Leto SM, et al.
J Mol Med (Berl). 2014 Jul;92(7):709-22. doi: 10.1007/s00109-014-1161-2. Epub 2014 May 10.
J Mol Med (Berl). 2014.
PMID: 24811491
Free PMC article.
Review.
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IGF2 is an actionable target that identifies a distinct subpopulation of colorectal cancer patients with marginal response to anti-EGFR therapies.
Zanella ER, Galimi F, Sassi F, Migliardi G, Cottino F, Leto SM, Lupo B, Erriquez J, Isella C, Comoglio PM, Medico E, Tejpar S, Budinská E, Trusolino L, Bertotti A.
Zanella ER, et al. Among authors: leto sm.
Sci Transl Med. 2015 Jan 28;7(272):272ra12. doi: 10.1126/scitranslmed.3010445.
Sci Transl Med. 2015.
PMID: 25632036
Free article.
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HER2 activating mutations are targets for colorectal cancer treatment.
Kavuri SM, Jain N, Galimi F, Cottino F, Leto SM, Migliardi G, Searleman AC, Shen W, Monsey J, Trusolino L, Jacobs SA, Bertotti A, Bose R.
Kavuri SM, et al. Among authors: leto sm.
Cancer Discov. 2015 Aug;5(8):832-41. doi: 10.1158/2159-8290.CD-14-1211.
Cancer Discov. 2015.
PMID: 26243863
Free PMC article.
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Sustained Inhibition of HER3 and EGFR Is Necessary to Induce Regression of HER2-Amplified Gastrointestinal Carcinomas.
Leto SM, Sassi F, Catalano I, Torri V, Migliardi G, Zanella ER, Throsby M, Bertotti A, Trusolino L.
Leto SM, et al.
Clin Cancer Res. 2015 Dec 15;21(24):5519-31. doi: 10.1158/1078-0432.CCR-14-3066. Epub 2015 Aug 21.
Clin Cancer Res. 2015.
PMID: 26296355
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Patient-derived tumor models: a more suitable tool for pre-clinical studies in colorectal cancer.
Rizzo G, Bertotti A, Leto SM, Vetrano S.
Rizzo G, et al. Among authors: leto sm.
J Exp Clin Cancer Res. 2021 Jun 1;40(1):178. doi: 10.1186/s13046-021-01970-2.
J Exp Clin Cancer Res. 2021.
PMID: 34074330
Free PMC article.
Review.
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Synthetic Lethal Interaction with BCL-XL Blockade Deepens Response to Cetuximab in Patient-Derived Models of Metastatic Colorectal Cancer.
Leto SM, Ferri M, Sassi F, Zanella ER, Cottino F, Vurchio V, Catalano I, Ferrero A, Zingaretti CC, Marchiò C, Grassi E, Trusolino L, Bertotti A.
Leto SM, et al.
Clin Cancer Res. 2023 Mar 14;29(6):1102-1113. doi: 10.1158/1078-0432.CCR-22-2550.
Clin Cancer Res. 2023.
PMID: 36622698
Free PMC article.
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Colorectal cancer patient-derived organoids and cell lines harboring ATRX and/or DAXX mutations lack Alternative Lengthening of Telomeres (ALT).
Falcinelli M, Dell'Omo G, Grassi E, Mariella E, Leto SM, Scardellato S, Lorenzato A, Arena S, Bertotti A, Trusolino L, Bardelli A, d'Adda di Fagagna F.
Falcinelli M, et al. Among authors: leto sm.
Cell Death Dis. 2023 Feb 9;14(2):96. doi: 10.1038/s41419-023-05640-3.
Cell Death Dis. 2023.
PMID: 36759506
Free PMC article.
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