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A meta-analysis of genome-wide association scans identifies IL18RAP, PTPN2, TAGAP, and PUS10 as shared risk loci for Crohn's disease and celiac disease.
Festen EA, Goyette P, Green T, Boucher G, Beauchamp C, Trynka G, Dubois PC, Lagacé C, Stokkers PC, Hommes DW, Barisani D, Palmieri O, Annese V, van Heel DA, Weersma RK, Daly MJ, Wijmenga C, Rioux JD. Festen EA, et al. Among authors: beauchamp c. PLoS Genet. 2011 Jan 27;7(1):e1001283. doi: 10.1371/journal.pgen.1001283. PLoS Genet. 2011. PMID: 21298027 Free PMC article.
The dichotomous pattern of IL-12r and IL-23R expression elucidates the role of IL-12 and IL-23 in inflammation.
Chognard G, Bellemare L, Pelletier AN, Dominguez-Punaro MC, Beauchamp C, Guyon MJ, Charron G, Morin N, Sivanesan D, Kuchroo V, Xavier R, Michnick SW, Chemtob S, Rioux JD, Lesage S. Chognard G, et al. Among authors: beauchamp c. PLoS One. 2014 Feb 21;9(2):e89092. doi: 10.1371/journal.pone.0089092. eCollection 2014. PLoS One. 2014. PMID: 24586521 Free PMC article.
Specific targeting of the IL-23 receptor, using a novel small peptide noncompetitive antagonist, decreases the inflammatory response.
Quiniou C, Domínguez-Punaro M, Cloutier F, Erfani A, Ennaciri J, Sivanesan D, Sanchez M, Chognard G, Hou X, Rivera JC, Beauchamp C, Charron G, Vilquin M, Kuchroo V, Michnick S, Rioux JD, Lesage S, Chemtob S. Quiniou C, et al. Among authors: beauchamp c. Am J Physiol Regul Integr Comp Physiol. 2014 Nov 15;307(10):R1216-30. doi: 10.1152/ajpregu.00540.2013. Epub 2014 Aug 20. Am J Physiol Regul Integr Comp Physiol. 2014. PMID: 25354400 Free article.
A Metabolic Signature of Mitochondrial Dysfunction Revealed through a Monogenic Form of Leigh Syndrome.
Thompson Legault J, Strittmatter L, Tardif J, Sharma R, Tremblay-Vaillancourt V, Aubut C, Boucher G, Clish CB, Cyr D, Daneault C, Waters PJ; LSFC Consortium; Vachon L, Morin C, Laprise C, Rioux JD, Mootha VK, Des Rosiers C. Thompson Legault J, et al. Cell Rep. 2015 Nov 3;13(5):981-9. doi: 10.1016/j.celrep.2015.09.054. Epub 2015 Oct 22. Cell Rep. 2015. PMID: 26565911 Free PMC article.
IL23R (Interleukin 23 Receptor) Variants Protective against Inflammatory Bowel Diseases (IBD) Display Loss of Function due to Impaired Protein Stability and Intracellular Trafficking.
Sivanesan D, Beauchamp C, Quinou C, Lee J, Lesage S, Chemtob S, Rioux JD, Michnick SW. Sivanesan D, et al. Among authors: beauchamp c. J Biol Chem. 2016 Apr 15;291(16):8673-85. doi: 10.1074/jbc.M116.715870. Epub 2016 Feb 17. J Biol Chem. 2016. PMID: 26887945 Free PMC article.
Loss of hepatic LRPPRC alters mitochondrial bioenergetics, regulation of permeability transition and trans-membrane ROS diffusion.
Cuillerier A, Honarmand S, Cadete VJJ, Ruiz M, Forest A, Deschênes S, Beauchamp C; LSFC Consortium; Charron G, Rioux JD, Des Rosiers C, Shoubridge EA, Burelle Y. Cuillerier A, et al. Among authors: beauchamp c. Hum Mol Genet. 2017 Aug 15;26(16):3186-3201. doi: 10.1093/hmg/ddx202. Hum Mol Genet. 2017. PMID: 28575497 Free PMC article.
Characterization of a Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Model for the Study of Variant Pathogenicity: Validation of a KCNJ2 Mutation.
Gélinas R, El Khoury N, Chaix MA, Beauchamp C, Alikashani A, Ethier N, Boucher G, Villeneuve L, Robb L, Latour F, Mondesert B, Rivard L, Goyette P, Talajic M, Fiset C, Rioux JD. Gélinas R, et al. Among authors: beauchamp c. Circ Cardiovasc Genet. 2017 Oct;10(5):e001755. doi: 10.1161/CIRCGENETICS.117.001755. Circ Cardiovasc Genet. 2017. PMID: 29021306
Lrrk2 alleles modulate inflammation during microbial infection of mice in a sex-dependent manner.
Shutinoski B, Hakimi M, Harmsen IE, Lunn M, Rocha J, Lengacher N, Zhou YY, Khan J, Nguyen A, Hake-Volling Q, El-Kodsi D, Li J, Alikashani A, Beauchamp C, Majithia J, Coombs K, Shimshek D, Marcogliese PC, Park DS, Rioux JD, Philpott DJ, Woulfe JM, Hayley S, Sad S, Tomlinson JJ, Brown EG, Schlossmacher MG. Shutinoski B, et al. Among authors: beauchamp c. Sci Transl Med. 2019 Sep 25;11(511):eaas9292. doi: 10.1126/scitranslmed.aas9292. Sci Transl Med. 2019. PMID: 31554740
197 results