Hegde PV - Search Results

1

Synthesis and biological evaluation of orally active prodrugs and analogs of para-aminosalicylic acid (PAS).

Hegde PV, Howe MD, Zimmerman MD, Boshoff HIM, Sharma S, Remache B, Jia Z, Pan Y, Baughn AD, Dartois V, Aldrich CC. Hegde PV, et al. Eur J Med Chem. 2022 Mar 15;232:114201. doi: 10.1016/j.ejmech.2022.114201. Epub 2022 Feb 19. Eur J Med Chem. 2022. PMID: 35219151 Free PMC article.

2

8-cyanobenzothiazinone analogs with potent antitubercular activity.

Zhang G, Sheng L, Hegde P, Li Y, Aldrich CC. Zhang G, et al. Med Chem Res. 2021;30(2):449-458. doi: 10.1007/s00044-020-02676-4. Epub 2021 Jan 13. Med Chem Res. 2021. PMID: 33462533 Free PMC article.

3

Mycobacterium tuberculosis PanD Structure-Function Analysis and Identification of a Potent Pyrazinoic Acid-Derived Enzyme Inhibitor.

Ragunathan P, Cole M, Latka C, Aragaw WW, Hegde P, Shin J, Subramanian Manimekalai MS, Rishikesan S, Aldrich CC, Dick T, Grüber G. Ragunathan P, et al. ACS Chem Biol. 2021 Jun 18;16(6):1030-1039. doi: 10.1021/acschembio.1c00131. Epub 2021 May 13. ACS Chem Biol. 2021. PMID: 33984234 Free PMC article.

4

Reinvestigation of the structure-activity relationships of isoniazid.

Hegde P, Boshoff HIM, Rusman Y, Aragaw WW, Salomon CE, Dick T, Aldrich CC. Hegde P, et al. Tuberculosis (Edinb). 2021 Jul;129:102100. doi: 10.1016/j.tube.2021.102100. Epub 2021 Jun 5. Tuberculosis (Edinb). 2021. PMID: 34116482 Free PMC article.

5

Innovative Strategies for the Construction of Diverse 1'-Modified C-Nucleoside Derivatives.

Panda S, Poudel TN, Hegde P, Aldrich CC. Panda S, et al. J Org Chem. 2021 Dec 3;86(23):16625-16640. doi: 10.1021/acs.joc.1c01920. Epub 2021 Nov 10. J Org Chem. 2021. PMID: 34756029

6

Structural and Mechanistic Insights into Mycobacterium abscessus Aspartate Decarboxylase PanD and a Pyrazinoic Acid-Derived Inhibitor.

Saw WG, Leow CY, Harikishore A, Shin J, Cole MS, Aragaw WW, Ragunathan P, Hegde P, Aldrich CC, Dick T, Grüber G. Saw WG, et al. ACS Infect Dis. 2022 Jul 8;8(7):1324-1335. doi: 10.1021/acsinfecdis.2c00133. Epub 2022 Jun 22. ACS Infect Dis. 2022. PMID: 35731701 Free PMC article.

7

β-Lactamase-Mediated Fragmentation: Historical Perspectives and Recent Advances in Diagnostics, Imaging, and Antibacterial Design.

Cole MS, Hegde PV, Aldrich CC. Cole MS, et al. Among authors: hegde pv. ACS Infect Dis. 2022 Oct 14;8(10):1992-2018. doi: 10.1021/acsinfecdis.2c00315. Epub 2022 Sep 1. ACS Infect Dis. 2022. PMID: 36048623 Review.

8

Identification of 5-(Aryl/Heteroaryl)amino-4-quinolones as Potent Membrane-Disrupting Agents to Combat Antibiotic-Resistant Gram-Positive Bacteria.

Schultz JR, Costa SK, Jachak GR, Hegde P, Zimmerman M, Pan Y, Josten M, Ejeh C, Hammerstad T, Sahl HG, Pereira PM, Pinho MG, Dartois V, Cheung A, Aldrich CC. Schultz JR, et al. J Med Chem. 2022 Oct 27;65(20):13910-13934. doi: 10.1021/acs.jmedchem.2c01151. Epub 2022 Oct 11. J Med Chem. 2022. PMID: 36219779 Free PMC article.

9

Redesign of Rifamycin Antibiotics to Overcome ADP-Ribosylation-Mediated Resistance.

Lan T, Ganapathy US, Sharma S, Ahn YM, Zimmerman M, Molodtsov V, Hegde P, Gengenbacher M, Ebright RH, Dartois V, Freundlich JS, Dick T, Aldrich CC. Lan T, et al. Angew Chem Int Ed Engl. 2022 Nov 7;61(45):e202211498. doi: 10.1002/anie.202211498. Epub 2022 Oct 12. Angew Chem Int Ed Engl. 2022. PMID: 36222275 Free PMC article.

10

1'-Cyano Intermediate Enables Rapid and Stereoretentive Access to 1'-Modified Remdesivir Nucleosides.

Poudel TN, Panda S, Orimoloye M, Hegde P, Aldrich CC. Poudel TN, et al. J Org Chem. 2022 Nov 4;87(21):14452-14462. doi: 10.1021/acs.joc.2c01897. Epub 2022 Oct 12. J Org Chem. 2022. PMID: 36223099

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