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Identification of 5-(Aryl/Heteroaryl)amino-4-quinolones as Potent Membrane-Disrupting Agents to Combat Antibiotic-Resistant Gram-Positive Bacteria.
Schultz JR, Costa SK, Jachak GR, Hegde P, Zimmerman M, Pan Y, Josten M, Ejeh C, Hammerstad T, Sahl HG, Pereira PM, Pinho MG, Dartois V, Cheung A, Aldrich CC. Schultz JR, et al. Among authors: pan y. J Med Chem. 2022 Oct 27;65(20):13910-13934. doi: 10.1021/acs.jmedchem.2c01151. Epub 2022 Oct 11. J Med Chem. 2022. PMID: 36219779 Free PMC article.
Targeting Mycobacterium tuberculosis response to environmental cues for the development of effective antitubercular drugs.
Lavin RC, Johnson C, Ahn YM, Kremiller KM, Sherwood M, Patel JS, Pan Y, Russo R, MacGilvary NJ, Giacalone D, Kevorkian YL, Zimmerman MD, Glickman JF, Freundlich JS, Tan S. Lavin RC, et al. Among authors: pan y. PLoS Biol. 2021 Jul 28;19(7):e3001355. doi: 10.1371/journal.pbio.3001355. eCollection 2021 Jul. PLoS Biol. 2021. PMID: 34319985 Free PMC article.
Discovery and Evaluation of Pyrazolo[3,4-d]pyridazinone as a Potent and Orally Active Irreversible BTK Inhibitor.
Zhang X, Sheng X, Shen J, Zhang S, Sun W, Shen C, Li Y, Wang J, Lv H, Cui M, Zhu Y, Huang L, Hao D, Qi Z, Sun G, Mao W, Pan Y, Shen L, Li X, Hu G, Gong Z, Han S, Li J, Chen S, Tu R, Wang X, Wu C. Zhang X, et al. Among authors: pan y. ACS Med Chem Lett. 2019 Dec 11;11(10):1863-1868. doi: 10.1021/acsmedchemlett.9b00395. eCollection 2020 Oct 8. ACS Med Chem Lett. 2019. PMID: 33062165 Free PMC article.
Discovery of Pyridopyrimidinones as Potent and Orally Active Dual Inhibitors of PI3K/mTOR.
Yu T, Li N, Wu C, Guan A, Li Y, Peng Z, He M, Li J, Gong Z, Huang L, Gao B, Hao D, Sun J, Pan Y, Shen L, Chan C, Lu X, Yuan H, Li Y, Li J, Chen S. Yu T, et al. Among authors: pan y. ACS Med Chem Lett. 2018 Feb 27;9(3):256-261. doi: 10.1021/acsmedchemlett.8b00002. eCollection 2018 Mar 8. ACS Med Chem Lett. 2018. PMID: 29541370 Free PMC article.
Discovery of Orally Bioavailable Ligand Efficient Quinazolindiones as Potent and Selective Tankyrases Inhibitors.
Qin D, Lin X, Liu Z, Chen Y, Zhang Z, Wu C, Liu L, Pan Y, Laquerre S, Emery J, Fergusson J, Roland K, Keenan R, Oliff A, Kumar S, Cheung M, Su DS. Qin D, et al. Among authors: pan y. ACS Med Chem Lett. 2021 May 13;12(6):1005-1010. doi: 10.1021/acsmedchemlett.1c00160. eCollection 2021 Jun 10. ACS Med Chem Lett. 2021. PMID: 34141085 Free PMC article.
Discovery of a First-in-Class Gut-Restricted RET Kinase Inhibitor as a Clinical Candidate for the Treatment of IBS.
Schenck Eidam H, Russell J, Raha K, DeMartino M, Qin D, Guan HA, Zhang Z, Zhen G, Yu H, Wu C, Pan Y, Joberty G, Zinn N, Laquerre S, Robinson S, White A, Giddings A, Mohammadi E, Greenwood-Van Meerveld B, Oliff A, Kumar S, Cheung M. Schenck Eidam H, et al. Among authors: pan y. ACS Med Chem Lett. 2018 May 24;9(7):623-628. doi: 10.1021/acsmedchemlett.8b00035. eCollection 2018 Jul 12. ACS Med Chem Lett. 2018. PMID: 30034590 Free PMC article.
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