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A cholinergic neuroskeletal interface promotes bone formation during postnatal growth and exercise.
Gadomski S, Fielding C, García-García A, Korn C, Kapeni C, Ashraf S, Villadiego J, Toro RD, Domingues O, Skepper JN, Michel T, Zimmer J, Sendtner R, Dillon S, Poole KES, Holdsworth G, Sendtner M, Toledo-Aral JJ, De Bari C, McCaskie AW, Robey PG, Méndez-Ferrer S. Gadomski S, et al. Among authors: holdsworth g. Cell Stem Cell. 2022 Apr 7;29(4):528-544.e9. doi: 10.1016/j.stem.2022.02.008. Epub 2022 Mar 10. Cell Stem Cell. 2022. PMID: 35276096 Free PMC article.
Characterization of the interaction of sclerostin with the low density lipoprotein receptor-related protein (LRP) family of Wnt co-receptors.
Holdsworth G, Slocombe P, Doyle C, Sweeney B, Veverka V, Le Riche K, Franklin RJ, Compson J, Brookings D, Turner J, Kennedy J, Garlish R, Shi J, Newnham L, McMillan D, Muzylak M, Carr MD, Henry AJ, Ceska T, Robinson MK. Holdsworth G, et al. J Biol Chem. 2012 Aug 3;287(32):26464-77. doi: 10.1074/jbc.M112.350108. Epub 2012 Jun 13. J Biol Chem. 2012. PMID: 22696217 Free PMC article.
Structural and functional analysis of Dickkopf 4 (Dkk4): New insights into Dkk evolution and regulation of Wnt signaling by Dkk and Kremen proteins.
Patel S, Barkell AM, Gupta D, Strong SL, Bruton S, Muskett FW, Addis PW, Renshaw PS, Slocombe PM, Doyle C, Clargo A, Taylor RJ, Prosser CE, Henry AJ, Robinson MK, Waters LC, Holdsworth G, Carr MD. Patel S, et al. Among authors: holdsworth g. J Biol Chem. 2018 Aug 3;293(31):12149-12166. doi: 10.1074/jbc.RA118.002918. Epub 2018 Jun 20. J Biol Chem. 2018. PMID: 29925589 Free PMC article.
Novel actions of sclerostin on bone.
Holdsworth G, Roberts SJ, Ke HZ. Holdsworth G, et al. J Mol Endocrinol. 2019 Feb 1;62(2):R167-R185. doi: 10.1530/JME-18-0176. J Mol Endocrinol. 2019. PMID: 30532996 Review.
Sclerostin Downregulation Globally by Naturally Occurring Genetic Variants, or Locally in Atherosclerotic Plaques, Does Not Associate With Cardiovascular Events in Humans.
Holdsworth G, Staley JR, Hall P, van Koeverden I, Vangjeli C, Okoye R, Boyce RW, Turk JR, Armstrong M, Wolfreys A, Pasterkamp G. Holdsworth G, et al. J Bone Miner Res. 2021 Jul;36(7):1326-1339. doi: 10.1002/jbmr.4287. Epub 2021 Mar 30. J Bone Miner Res. 2021. PMID: 33784435 Free PMC article.
80 results