Mechanism of Tripeptide Trimming of Amyloid β-Peptide 49 by γ-Secretase.
Bhattarai A, Devkota S, Do HN, Wang J, Bhattarai S, Wolfe MS, Miao Y.
Bhattarai A, et al. Among authors: bhattarai s.
J Am Chem Soc. 2022 Apr 13;144(14):6215-6226. doi: 10.1021/jacs.1c10533. Epub 2022 Apr 4.
J Am Chem Soc. 2022.
PMID: 35377629
Free PMC article.
The membrane-embedded gamma-secretase complex processively cleaves within the transmembrane domain of amyloid precursor protein (APP) to produce 37-to-43-residue amyloid beta-peptides (Abeta) of Alzheimer's disease (AD). Despite its importance in pathogenesis, the mechanis …
The membrane-embedded gamma-secretase complex processively cleaves within the transmembrane domain of amyloid precursor protein (APP) to pro …