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Designed Helical Peptides as Functional Probes for γ-Secretase.
Philip AT, Devkota S, Malvankar S, Bhattarai S, Meneely KM, Williams TD, Wolfe MS. Philip AT, et al. Among authors: bhattarai s. Biochemistry. 2019 Nov 5;58(44):4398-4407. doi: 10.1021/acs.biochem.9b00639. Epub 2019 Oct 28. Biochemistry. 2019. PMID: 31625391 Free PMC article.
Mechanisms of γ-Secretase Activation and Substrate Processing.
Bhattarai A, Devkota S, Bhattarai S, Wolfe MS, Miao Y. Bhattarai A, et al. Among authors: bhattarai s. ACS Cent Sci. 2020 Jun 24;6(6):969-983. doi: 10.1021/acscentsci.0c00296. Epub 2020 Jun 4. ACS Cent Sci. 2020. PMID: 32607444 Free PMC article.
Mechanism of Tripeptide Trimming of Amyloid β-Peptide 49 by γ-Secretase.
Bhattarai A, Devkota S, Do HN, Wang J, Bhattarai S, Wolfe MS, Miao Y. Bhattarai A, et al. Among authors: bhattarai s. J Am Chem Soc. 2022 Apr 13;144(14):6215-6226. doi: 10.1021/jacs.1c10533. Epub 2022 Apr 4. J Am Chem Soc. 2022. PMID: 35377629 Free PMC article.
The membrane-embedded gamma-secretase complex processively cleaves within the transmembrane domain of amyloid precursor protein (APP) to produce 37-to-43-residue amyloid beta-peptides (Abeta) of Alzheimer's disease (AD). Despite its importance in pathogenesis, the mechanis …
The membrane-embedded gamma-secretase complex processively cleaves within the transmembrane domain of amyloid precursor protein (APP) to pro …
Familial Alzheimer mutations stabilize synaptotoxic γ-secretase-substrate complexes.
Devkota S, Zhou R, Nagarajan V, Maesako M, Do H, Noorani A, Overmeyer C, Bhattarai S, Douglas JT, Saraf A, Miao Y, Ackley BD, Shi Y, Wolfe MS. Devkota S, et al. Among authors: bhattarai s. Cell Rep. 2024 Feb 27;43(2):113761. doi: 10.1016/j.celrep.2024.113761. Epub 2024 Feb 13. Cell Rep. 2024. PMID: 38349793 Free PMC article.
498 results