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Combinatorial optimization of mRNA structure, stability, and translation for RNA-based therapeutics.
Leppek K, Byeon GW, Kladwang W, Wayment-Steele HK, Kerr CH, Xu AF, Kim DS, Topkar VV, Choe C, Rothschild D, Tiu GC, Wellington-Oguri R, Fujii K, Sharma E, Watkins AM, Nicol JJ, Romano J, Tunguz B, Diaz F, Cai H, Guo P, Wu J, Meng F, Shi S, Participants E, Dormitzer PR, Solórzano A, Barna M, Das R. Leppek K, et al. Among authors: watkins am. Nat Commun. 2022 Mar 22;13(1):1536. doi: 10.1038/s41467-022-28776-w. Nat Commun. 2022. PMID: 35318324 Free PMC article.
Theoretical basis for stabilizing messenger RNA through secondary structure design.
Wayment-Steele HK, Kim DS, Choe CA, Nicol JJ, Wellington-Oguri R, Watkins AM, Parra Sperberg RA, Huang PS, Participants E, Das R. Wayment-Steele HK, et al. Among authors: watkins am. Nucleic Acids Res. 2021 Oct 11;49(18):10604-10617. doi: 10.1093/nar/gkab764. Nucleic Acids Res. 2021. PMID: 34520542 Free PMC article.
Accelerated cryo-EM-guided determination of three-dimensional RNA-only structures.
Kappel K, Zhang K, Su Z, Watkins AM, Kladwang W, Li S, Pintilie G, Topkar VV, Rangan R, Zheludev IN, Yesselman JD, Chiu W, Das R. Kappel K, et al. Among authors: watkins am. Nat Methods. 2020 Jul;17(7):699-707. doi: 10.1038/s41592-020-0878-9. Epub 2020 Jul 2. Nat Methods. 2020. PMID: 32616928 Free PMC article.
Using Rosetta for RNA homology modeling.
Watkins AM, Rangan R, Das R. Watkins AM, et al. Methods Enzymol. 2019;623:177-207. doi: 10.1016/bs.mie.2019.05.026. Epub 2019 Jun 11. Methods Enzymol. 2019. PMID: 31239046 Free PMC article.
68 results