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Tackling the emerging threat of antifungal resistance to human health.
Fisher MC, Alastruey-Izquierdo A, Berman J, Bicanic T, Bignell EM, Bowyer P, Bromley M, Brüggemann R, Garber G, Cornely OA, Gurr SJ, Harrison TS, Kuijper E, Rhodes J, Sheppard DC, Warris A, White PL, Xu J, Zwaan B, Verweij PE. Fisher MC, et al. Among authors: bignell em. Nat Rev Microbiol. 2022 Sep;20(9):557-571. doi: 10.1038/s41579-022-00720-1. Epub 2022 Mar 29. Nat Rev Microbiol. 2022. PMID: 35352028 Free PMC article. Review.
Pseudomonas aeruginosa-Derived Volatile Sulfur Compounds Promote Distal Aspergillus fumigatus Growth and a Synergistic Pathogen-Pathogen Interaction That Increases Pathogenicity in Co-infection.
Scott J, Sueiro-Olivares M, Ahmed W, Heddergott C, Zhao C, Thomas R, Bromley M, Latgé JP, Krappmann S, Fowler S, Bignell E, Amich J. Scott J, et al. Front Microbiol. 2019 Oct 9;10:2311. doi: 10.3389/fmicb.2019.02311. eCollection 2019. Front Microbiol. 2019. PMID: 31649650 Free PMC article.
The negative cofactor 2 complex is a key regulator of drug resistance in Aspergillus fumigatus.
Furukawa T, van Rhijn N, Fraczek M, Gsaller F, Davies E, Carr P, Gago S, Fortune-Grant R, Rahman S, Gilsenan JM, Houlder E, Kowalski CH, Raj S, Paul S, Cook P, Parker JE, Kelly S, Cramer RA, Latgé JP, Moye-Rowley S, Bignell E, Bowyer P, Bromley MJ. Furukawa T, et al. Nat Commun. 2020 Jan 22;11(1):427. doi: 10.1038/s41467-019-14191-1. Nat Commun. 2020. PMID: 31969561 Free PMC article.
Fungal and host protein persulfidation are functionally correlated and modulate both virulence and antifungal response.
Sueiro-Olivares M, Scott J, Gago S, Petrovic D, Kouroussis E, Zivanovic J, Yu Y, Strobel M, Cunha C, Thomson D, Fortune-Grant R, Thusek S, Bowyer P, Beilhack A, Carvalho A, Bignell E, Filipovic MR, Amich J. Sueiro-Olivares M, et al. PLoS Biol. 2021 Jun 1;19(6):e3001247. doi: 10.1371/journal.pbio.3001247. eCollection 2021 Jun. PLoS Biol. 2021. PMID: 34061822 Free PMC article.
73 results