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A modified vaccinia Ankara vaccine expressing spike and nucleocapsid protects rhesus macaques against SARS-CoV-2 Delta infection.
Routhu NK, Gangadhara S, Lai L, Davis-Gardner ME, Floyd K, Shiferaw A, Bartsch YC, Fischinger S, Khoury G, Rahman SA, Stampfer SD, Schäfer A, Jean SM, Wallace C, Stammen RL, Wood J, Joyce C, Nagy T, Parsons MS, Gralinski L, Kozlowski PA, Alter G, Suthar MS, Amara RR. Routhu NK, et al. Among authors: jean sm. Sci Immunol. 2022 Jun 24;7(72):eabo0226. doi: 10.1126/sciimmunol.abo0226. Epub 2022 Jun 24. Sci Immunol. 2022. PMID: 35357886 Free PMC article.
Postnatal Zika virus infection is associated with persistent abnormalities in brain structure, function, and behavior in infant macaques.
Mavigner M, Raper J, Kovacs-Balint Z, Gumber S, O'Neal JT, Bhaumik SK, Zhang X, Habib J, Mattingly C, McDonald CE, Avanzato V, Burke MW, Magnani DM, Bailey VK, Watkins DI, Vanderford TH, Fair D, Earl E, Feczko E, Styner M, Jean SM, Cohen JK, Silvestri G, Johnson RP, O'Connor DH, Wrammert J, Suthar MS, Sanchez MM, Alvarado MC, Chahroudi A. Mavigner M, et al. Among authors: jean sm. Sci Transl Med. 2018 Apr 4;10(435):eaao6975. doi: 10.1126/scitranslmed.aao6975. Sci Transl Med. 2018. PMID: 29618564 Free PMC article.
Baricitinib treatment resolves lower airway inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques.
Hoang TN, Pino M, Boddapati AK, Viox EG, Starke CE, Upadhyay AA, Gumber S, Busman-Sahay K, Strongin Z, Harper JL, Tharp GK, Pellegrini KL, Kirejczyk S, Zandi K, Tao S, Horton TR, Beagle EN, Mahar EA, Lee MY, Cohen J, Jean SM, Wood JS, Connor-Stroud F, Stammen RL, Delmas OM, Wang S, Cooney KA, Sayegh MN, Wang L, Weiskopf D, Filev PD, Waggoner J, Piantadosi A, Kasturi SP, Al-Shakhshir H, Ribeiro SP, Sekaly RP, Levit RD, Estes JD, Vanderford TH, Schinazi RF, Bosinger SE, Paiardini M. Hoang TN, et al. Among authors: jean sm. bioRxiv [Preprint]. 2020 Sep 16:2020.09.16.300277. doi: 10.1101/2020.09.16.300277. bioRxiv. 2020. PMID: 32995780 Free PMC article. Updated. Preprint.
Baricitinib treatment resolves lower-airway macrophage inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques.
Hoang TN, Pino M, Boddapati AK, Viox EG, Starke CE, Upadhyay AA, Gumber S, Nekorchuk M, Busman-Sahay K, Strongin Z, Harper JL, Tharp GK, Pellegrini KL, Kirejczyk S, Zandi K, Tao S, Horton TR, Beagle EN, Mahar EA, Lee MYH, Cohen J, Jean SM, Wood JS, Connor-Stroud F, Stammen RL, Delmas OM, Wang S, Cooney KA, Sayegh MN, Wang L, Filev PD, Weiskopf D, Silvestri G, Waggoner J, Piantadosi A, Kasturi SP, Al-Shakhshir H, Ribeiro SP, Sekaly RP, Levit RD, Estes JD, Vanderford TH, Schinazi RF, Bosinger SE, Paiardini M. Hoang TN, et al. Among authors: jean sm. Cell. 2021 Jan 21;184(2):460-475.e21. doi: 10.1016/j.cell.2020.11.007. Epub 2020 Nov 10. Cell. 2021. PMID: 33278358 Free PMC article.
A modified vaccinia Ankara vector-based vaccine protects macaques from SARS-CoV-2 infection, immune pathology, and dysfunction in the lungs.
Routhu NK, Cheedarla N, Gangadhara S, Bollimpelli VS, Boddapati AK, Shiferaw A, Rahman SA, Sahoo A, Edara VV, Lai L, Floyd K, Wang S, Fischinger S, Atyeo C, Shin SA, Gumber S, Kirejczyk S, Cohen J, Jean SM, Wood JS, Connor-Stroud F, Stammen RL, Upadhyay AA, Pellegrini K, Montefiori D, Shi PY, Menachery VD, Alter G, Vanderford TH, Bosinger SE, Suthar MS, Amara RR. Routhu NK, et al. Among authors: jean sm. Immunity. 2021 Mar 9;54(3):542-556.e9. doi: 10.1016/j.immuni.2021.02.001. Epub 2021 Feb 4. Immunity. 2021. PMID: 33631118 Free PMC article.
A yeast expressed RBD-based SARS-CoV-2 vaccine formulated with 3M-052-alum adjuvant promotes protective efficacy in non-human primates.
Pino M, Abid T, Pereira Ribeiro S, Edara VV, Floyd K, Smith JC, Latif MB, Pacheco-Sanchez G, Dutta D, Wang S, Gumber S, Kirejczyk S, Cohen J, Stammen RL, Jean SM, Wood JS, Connor-Stroud F, Pollet J, Chen WH, Wei J, Zhan B, Lee J, Liu Z, Strych U, Shenvi N, Easley K, Weiskopf D, Sette A, Pollara J, Mielke D, Gao H, Eisel N, LaBranche CC, Shen X, Ferrari G, Tomaras GD, Montefiori DC, Sekaly RP, Vanderford TH, Tomai MA, Fox CB, Suthar MS, Kozlowski PA, Hotez PJ, Paiardini M, Bottazzi ME, Kasturi SP. Pino M, et al. Among authors: jean sm. Sci Immunol. 2021 Jul 15;6(61):eabh3634. doi: 10.1126/sciimmunol.abh3634. Sci Immunol. 2021. PMID: 34266981 Free PMC article.
Altered Response Pattern following AZD5582 Treatment of SIV-Infected, ART-Suppressed Rhesus Macaque Infants.
Bricker KM, Obregon-Perko V, Williams B, Oliver D, Uddin F, Neja M, Hopkins L, Dashti A, Jean S, Wood JS, Ehnert S, Liang S, Vanderford T, Tharp GK, Bosinger SE, Schauer AP, Mavigner M, Cottrell ML, Margolis D, Dunham RM, Chahroudi A. Bricker KM, et al. J Virol. 2022 Apr 13;96(7):e0169921. doi: 10.1128/jvi.01699-21. Epub 2022 Mar 16. J Virol. 2022. PMID: 35293766 Free PMC article.
Efficacy of mRNA-1273 and Novavax ancestral or BA.1 spike booster vaccines against SARS-CoV-2 BA.5 infection in nonhuman primates.
Routhu NK, Stampfer SD, Lai L, Akhtar A, Tong X, Yuan D, Chicz TM, McNamara RP, Jakkala K, Davis-Gardner ME, St Pierre EL, Smith B, Green KM, Golden N, Picou B, Jean SM, Wood J, Cohen J, Moore IN, Patel N, Guebre-Xabier M, Smith G, Glenn G, Kozlowski PA, Alter G, Ahmed R, Suthar MS, Amara RR. Routhu NK, et al. Among authors: jean sm. Sci Immunol. 2023 Oct 27;8(88):eadg7015. doi: 10.1126/sciimmunol.adg7015. Epub 2023 Oct 27. Sci Immunol. 2023. PMID: 37191508 Free PMC article.
Neutralizing human monoclonal antibodies prevent Zika virus infection in macaques.
Magnani DM, Rogers TF, Beutler N, Ricciardi MJ, Bailey VK, Gonzalez-Nieto L, Briney B, Sok D, Le K, Strubel A, Gutman MJ, Pedreño-Lopez N, Grubaugh ND, Silveira CGT, Maxwell HS, Domingues A, Martins MA, Lee DE, Okwuazi EE, Jean S, Strobert EA, Chahroudi A, Silvestri G, Vanderford TH, Kallas EG, Desrosiers RC, Bonaldo MC, Whitehead SS, Burton DR, Watkins DI. Magnani DM, et al. Sci Transl Med. 2017 Oct 4;9(410):eaan8184. doi: 10.1126/scitranslmed.aan8184. Sci Transl Med. 2017. PMID: 28978754 Free PMC article.
30 results