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Polygenic transcriptome risk scores for COPD and lung function improve cross-ethnic portability of prediction in the NHLBI TOPMed program.
Hu X, Qiao D, Kim W, Moll M, Balte PP, Lange LA, Bartz TM, Kumar R, Li X, Yu B, Cade BE, Laurie CA, Sofer T, Ruczinski I, Nickerson DA, Muzny DM, Metcalf GA, Doddapaneni H, Gabriel S, Gupta N, Dugan-Perez S, Cupples LA, Loehr LR, Jain D, Rotter JI, Wilson JG, Psaty BM, Fornage M, Morrison AC, Vasan RS, Washko G, Rich SS, O'Connor GT, Bleecker E, Kaplan RC, Kalhan R, Redline S, Gharib SA, Meyers D, Ortega V, Dupuis J, London SJ, Lappalainen T, Oelsner EC, Silverman EK, Barr RG, Thornton TA, Wheeler HE; TOPMed Lung Working Group; Cho MH, Im HK, Manichaikul A. Hu X, et al. Among authors: ortega v. Am J Hum Genet. 2022 May 5;109(5):857-870. doi: 10.1016/j.ajhg.2022.03.007. Epub 2022 Apr 5. Am J Hum Genet. 2022. PMID: 35385699 Free PMC article.
A Roadmap to functional genomics.
Penn RB, Ortega VE, Bleecker ER. Penn RB, et al. Physiol Genomics. 2007 Jun 19;30(1):82-8. doi: 10.1152/physiolgenomics.00010.2007. Epub 2007 Feb 27. Physiol Genomics. 2007. PMID: 17327496
Pharmacogenetics of the beta 2-adrenergic receptor gene.
Ortega VE, Hawkins GA, Peters SP, Bleecker ER. Ortega VE, et al. Immunol Allergy Clin North Am. 2007 Nov;27(4):665-84; vii. doi: 10.1016/j.iac.2007.09.007. Immunol Allergy Clin North Am. 2007. PMID: 17996583 Free PMC article. Review.
Biomarker surrogates do not accurately predict sputum eosinophil and neutrophil percentages in asthmatic subjects.
Hastie AT, Moore WC, Li H, Rector BM, Ortega VE, Pascual RM, Peters SP, Meyers DA, Bleecker ER; National Heart, Lung, and Blood Institute's Severe Asthma Research Program. Hastie AT, et al. J Allergy Clin Immunol. 2013 Jul;132(1):72-80. doi: 10.1016/j.jaci.2013.03.044. Epub 2013 May 21. J Allergy Clin Immunol. 2013. PMID: 23706399 Free PMC article.
Effect of rare variants in ADRB2 on risk of severe exacerbations and symptom control during longacting β agonist treatment in a multiethnic asthma population: a genetic study.
Ortega VE, Hawkins GA, Moore WC, Hastie AT, Ampleford EJ, Busse WW, Castro M, Chardon D, Erzurum SC, Israel E, Montealegre F, Wenzel SE, Peters SP, Meyers DA, Bleecker ER. Ortega VE, et al. Lancet Respir Med. 2014 Mar;2(3):204-13. doi: 10.1016/S2213-2600(13)70289-3. Epub 2014 Jan 27. Lancet Respir Med. 2014. PMID: 24621682 Free PMC article.
Challenges and disparities in the application of personalized genomic medicine to populations with African ancestry.
Kessler MD, Yerges-Armstrong L, Taub MA, Shetty AC, Maloney K, Jeng LJB, Ruczinski I, Levin AM, Williams LK, Beaty TH, Mathias RA, Barnes KC; Consortium on Asthma among African-ancestry Populations in the Americas (CAAPA); O'Connor TD. Kessler MD, et al. Nat Commun. 2016 Oct 11;7:12521. doi: 10.1038/ncomms12521. Nat Commun. 2016. PMID: 27725664 Free PMC article.
298 results