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TLR7 gain-of-function genetic variation causes human lupus.
Brown GJ, Cañete PF, Wang H, Medhavy A, Bones J, Roco JA, He Y, Qin Y, Cappello J, Ellyard JI, Bassett K, Shen Q, Burgio G, Zhang Y, Turnbull C, Meng X, Wu P, Cho E, Miosge LA, Andrews TD, Field MA, Tvorogov D, Lopez AF, Babon JJ, López CA, Gónzalez-Murillo Á, Garulo DC, Pascual V, Levy T, Mallack EJ, Calame DG, Lotze T, Lupski JR, Ding H, Ullah TR, Walters GD, Koina ME, Cook MC, Shen N, de Lucas Collantes C, Corry B, Gantier MP, Athanasopoulos V, Vinuesa CG. Brown GJ, et al. Among authors: gantier mp. Nature. 2022 May;605(7909):349-356. doi: 10.1038/s41586-022-04642-z. Epub 2022 Apr 27. Nature. 2022. PMID: 35477763 Free PMC article.
Connexin-Dependent Transfer of cGAMP to Phagocytes Modulates Antiviral Responses.
Pépin G, De Nardo D, Rootes CL, Ullah TR, Al-Asmari SS, Balka KR, Li HM, Quinn KM, Moghaddas F, Chappaz S, Kile BT, Morand EF, Masters SL, Stewart CR, Williams BRG, Gantier MP. Pépin G, et al. Among authors: gantier mp. mBio. 2020 Jan 28;11(1):e03187-19. doi: 10.1128/mBio.03187-19. mBio. 2020. PMID: 31992625 Free PMC article.
Sequence-dependent inhibition of cGAS and TLR9 DNA sensing by 2'-O-methyl gapmer oligonucleotides.
Valentin R, Wong C, Alharbi AS, Pradeloux S, Morros MP, Lennox KA, Ellyard JI, Garcin AJ, Ullah TR, Kusuma GD, Pépin G, Li HM, Pearson JS, Ferrand J, Lim R, Veedu RN, Morand EF, Vinuesa CG, Behlke MA, Gantier MP. Valentin R, et al. Among authors: gantier mp. Nucleic Acids Res. 2021 Jun 21;49(11):6082-6099. doi: 10.1093/nar/gkab451. Nucleic Acids Res. 2021. PMID: 34057477 Free PMC article.
Deficiency in coatomer complex I causes aberrant activation of STING signalling.
Steiner A, Hrovat-Schaale K, Prigione I, Yu CH, Laohamonthonkul P, Harapas CR, Low RRJ, De Nardo D, Dagley LF, Mlodzianoski MJ, Rogers KL, Zillinger T, Hartmann G, Gantier MP, Gattorno M, Geyer M, Volpi S, Davidson S, Masters SL. Steiner A, et al. Among authors: gantier mp. Nat Commun. 2022 Apr 28;13(1):2321. doi: 10.1038/s41467-022-29946-6. Nat Commun. 2022. PMID: 35484149 Free PMC article.
Genistein Targets STING-Driven Antiviral Responses.
Ullah TR, Balka KR, Ambrose RL, Pépin G, Wilce MCJ, Wilce JA, Thomas BJ, De Nardo D, Williams BRG, Gantier MP. Ullah TR, et al. Among authors: gantier mp. mBio. 2022 Aug 30;13(4):e0206422. doi: 10.1128/mbio.02064-22. Epub 2022 Aug 4. mBio. 2022. PMID: 35924852 Free PMC article.
Pharmacological inhibition of TBK1/IKKε blunts immunopathology in a murine model of SARS-CoV-2 infection.
Ullah TR, Johansen MD, Balka KR, Ambrose RL, Gearing LJ, Roest J, Vivian JP, Sapkota S, Jayasekara WSN, Wenholz DS, Aldilla VR, Zeng J, Miemczyk S, Nguyen DH, Hansbro NG, Venkatraman R, Kang JH, Pang ES, Thomas BJ, Alharbi AS, Rezwan R, O'Keeffe M, Donald WA, Ellyard JI, Wong W, Kumar N, Kile BT, Vinuesa CG, Kelly GE, Laczka OF, Hansbro PM, De Nardo D, Gantier MP. Ullah TR, et al. Among authors: gantier mp. Nat Commun. 2023 Sep 18;14(1):5666. doi: 10.1038/s41467-023-41381-9. Nat Commun. 2023. PMID: 37723181 Free PMC article.
Inosine-mediated modulation of RNA sensing by Toll-like receptor 7 (TLR7) and TLR8.
Sarvestani ST, Tate MD, Moffat JM, Jacobi AM, Behlke MA, Miller AR, Beckham SA, McCoy CE, Chen W, Mintern JD, O'Keeffe M, John M, Williams BR, Gantier MP. Sarvestani ST, et al. Among authors: gantier mp. J Virol. 2014 Jan;88(2):799-810. doi: 10.1128/JVI.01571-13. Epub 2013 Nov 13. J Virol. 2014. PMID: 24227841 Free PMC article.
81 results