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Chronic inflammatory arthritis drives systemic changes in circadian energy metabolism.
Downton P, Sanna F, Maidstone R, Poolman TM, Hayter EA, Dickson SH, Ciccone NA, Early JO, Adamson A, Spiller DG, Simpkins DA, Baxter M, Fischer R, Rattray M, Loudon ASI, Gibbs JE, Bechtold DA, Ray DW. Downton P, et al. Among authors: loudon asi. Proc Natl Acad Sci U S A. 2022 May 3;119(18):e2112781119. doi: 10.1073/pnas.2112781119. Epub 2022 Apr 28. Proc Natl Acad Sci U S A. 2022. PMID: 35482925 Free PMC article.
The circadian clock protein REVERBα inhibits pulmonary fibrosis development.
Cunningham PS, Meijer P, Nazgiewicz A, Anderson SG, Borthwick LA, Bagnall J, Kitchen GB, Lodyga M, Begley N, Venkateswaran RV, Shah R, Mercer PF, Durrington HJ, Henderson NC, Piper-Hanley K, Fisher AJ, Chambers RC, Bechtold DA, Gibbs JE, Loudon AS, Rutter MK, Hinz B, Ray DW, Blaikley JF. Cunningham PS, et al. Proc Natl Acad Sci U S A. 2020 Jan 14;117(2):1139-1147. doi: 10.1073/pnas.1912109117. Epub 2019 Dec 26. Proc Natl Acad Sci U S A. 2020. PMID: 31879343 Free PMC article.
The clock gene Bmal1 inhibits macrophage motility, phagocytosis, and impairs defense against pneumonia.
Kitchen GB, Cunningham PS, Poolman TM, Iqbal M, Maidstone R, Baxter M, Bagnall J, Begley N, Saer B, Hussell T, Matthews LC, Dockrell DH, Durrington HJ, Gibbs JE, Blaikley JF, Loudon AS, Ray DW. Kitchen GB, et al. Proc Natl Acad Sci U S A. 2020 Jan 21;117(3):1543-1551. doi: 10.1073/pnas.1915932117. Epub 2020 Jan 3. Proc Natl Acad Sci U S A. 2020. PMID: 31900362 Free PMC article.
Nuclear receptor REVERBα is a state-dependent regulator of liver energy metabolism.
Hunter AL, Pelekanou CE, Adamson A, Downton P, Barron NJ, Cornfield T, Poolman TM, Humphreys N, Cunningham PS, Hodson L, Loudon ASI, Iqbal M, Bechtold DA, Ray DW. Hunter AL, et al. Among authors: loudon asi. Proc Natl Acad Sci U S A. 2020 Oct 13;117(41):25869-25879. doi: 10.1073/pnas.2005330117. Epub 2020 Sep 28. Proc Natl Acad Sci U S A. 2020. PMID: 32989157 Free PMC article.
Rheumatoid arthritis reprograms circadian output pathways.
Poolman TM, Gibbs J, Walker AL, Dickson S, Farrell L, Hensman J, Kendall AC, Maidstone R, Warwood S, Loudon A, Rattray M, Bruce IN, Nicolaou A, Ray DW. Poolman TM, et al. Arthritis Res Ther. 2019 Feb 6;21(1):47. doi: 10.1186/s13075-019-1825-y. Arthritis Res Ther. 2019. PMID: 30728072 Free PMC article.
The circadian clock regulates inflammatory arthritis.
Hand LE, Hopwood TW, Dickson SH, Walker AL, Loudon AS, Ray DW, Bechtold DA, Gibbs JE. Hand LE, et al. FASEB J. 2016 Nov;30(11):3759-3770. doi: 10.1096/fj.201600353R. Epub 2016 Aug 3. FASEB J. 2016. PMID: 27488122 Free PMC article.
The circadian clock and asthma.
Durrington HJ, Farrow SN, Loudon AS, Ray DW. Durrington HJ, et al. Thorax. 2014 Jan;69(1):90-2. doi: 10.1136/thoraxjnl-2013-203482. Epub 2013 May 23. Thorax. 2014. PMID: 23704227
167 results