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A NAC domain mutation (E83Q) unlocks the pathogenicity of human alpha-synuclein and recapitulates its pathological diversity.
Kumar ST, Mahul-Mellier AL, Hegde RN, Rivière G, Moons R, Ibáñez de Opakua A, Magalhães P, Rostami I, Donzelli S, Sobott F, Zweckstetter M, Lashuel HA. Kumar ST, et al. Among authors: donzelli s. Sci Adv. 2022 Apr 29;8(17):eabn0044. doi: 10.1126/sciadv.abn0044. Epub 2022 Apr 29. Sci Adv. 2022. PMID: 35486726 Free PMC article.
A simple, versatile and robust centrifugation-based filtration protocol for the isolation and quantification of α-synuclein monomers, oligomers and fibrils: Towards improving experimental reproducibility in α-synuclein research.
Kumar ST, Donzelli S, Chiki A, Syed MMK, Lashuel HA. Kumar ST, et al. Among authors: donzelli s. J Neurochem. 2020 Apr;153(1):103-119. doi: 10.1111/jnc.14955. Epub 2020 Feb 25. J Neurochem. 2020. PMID: 31925956 Free PMC article.
Revisiting the specificity and ability of phospho-S129 antibodies to capture alpha-synuclein biochemical and pathological diversity.
Lashuel HA, Mahul-Mellier AL, Novello S, Hegde RN, Jasiqi Y, Altay MF, Donzelli S, DeGuire SM, Burai R, Magalhães P, Chiki A, Ricci J, Boussouf M, Sadek A, Stoops E, Iseli C, Guex N. Lashuel HA, et al. Among authors: donzelli s. NPJ Parkinsons Dis. 2022 Oct 20;8(1):136. doi: 10.1038/s41531-022-00388-7. NPJ Parkinsons Dis. 2022. PMID: 36266318 Free PMC article.
Oxidant sensor in the cGMP-binding pocket of PKGIα regulates nitroxyl-mediated kinase activity.
Donzelli S, Goetz M, Schmidt K, Wolters M, Stathopoulou K, Diering S, Prysyazhna O, Polat V, Scotcher J, Dees C, Subramanian H, Butt E, Kamynina A, Schobesberger S, King SB, Nikolaev VO, de Wit C, Leichert LI, Feil R, Eaton P, Cuello F. Donzelli S, et al. Sci Rep. 2017 Aug 30;7(1):9938. doi: 10.1038/s41598-017-09275-1. Sci Rep. 2017. PMID: 28855531 Free PMC article.
Receptor-independent modulation of cAMP-dependent protein kinase and protein phosphatase signaling in cardiac myocytes by oxidizing agents.
Diering S, Stathopoulou K, Goetz M, Rathjens L, Harder S, Piasecki A, Raabe J, Schulz S, Brandt M, Pflaumenbaum J, Fuchs U, Donzelli S, Sadayappan S, Nikolaev VO, Flenner F, Ehler E, Cuello F. Diering S, et al. Among authors: donzelli s. J Biol Chem. 2020 Nov 6;295(45):15342-15365. doi: 10.1074/jbc.RA120.014467. Epub 2020 Aug 31. J Biol Chem. 2020. PMID: 32868295 Free PMC article.
S-glutathiolation impairs phosphoregulation and function of cardiac myosin-binding protein C in human heart failure.
Stathopoulou K, Wittig I, Heidler J, Piasecki A, Richter F, Diering S, van der Velden J, Buck F, Donzelli S, Schröder E, Wijnker PJ, Voigt N, Dobrev D, Sadayappan S, Eschenhagen T, Carrier L, Eaton P, Cuello F. Stathopoulou K, et al. Among authors: donzelli s. FASEB J. 2016 May;30(5):1849-64. doi: 10.1096/fj.201500048. Epub 2016 Feb 2. FASEB J. 2016. PMID: 26839380 Free PMC article.
-Stathopoulou, K., Wittig, I., Heidler, J., Piasecki, A., Richter, F., Diering, S., van der Velden, J., Buck, F., Donzelli, S., Schroder, E., Wijnker, P. J. M., Voigt, N., Dobrev, D., Sadayappan, S., Eschenhagen, T., Carrier, L., Eaton, P., Cuello, F. …
-Stathopoulou, K., Wittig, I., Heidler, J., Piasecki, A., Richter, F., Diering, S., van der Velden, J., Buck, F., Donzelli, …
Nitroxyl exacerbates ischemic cerebral injury and oxidative neurotoxicity.
Choe CU, Lewerenz J, Fischer G, Uliasz TF, Espey MG, Hummel FC, King SB, Schwedhelm E, Böger RH, Gerloff C, Hewett SJ, Magnus T, Donzelli S. Choe CU, et al. Among authors: donzelli s. J Neurochem. 2009 Sep;110(6):1766-73. doi: 10.1111/j.1471-4159.2009.06266.x. Epub 2009 Jul 8. J Neurochem. 2009. PMID: 19619135 Free article.
The new HNO donor, 1-nitrosocyclohexyl acetate, increases contractile force in normal and β-adrenergically desensitized ventricular myocytes.
El-Armouche A, Wahab A, Wittköpper K, Schulze T, Böttcher F, Pohlmann L, King SB, DuMond JF, Gerloff C, Böger RH, Eschenhagen T, Carrier L, Donzelli S. El-Armouche A, et al. Among authors: donzelli s. Biochem Biophys Res Commun. 2010 Nov 12;402(2):340-4. doi: 10.1016/j.bbrc.2010.10.030. Epub 2010 Oct 12. Biochem Biophys Res Commun. 2010. PMID: 20946877
Nitroxyl in the central nervous system.
Choe CU, Lewerenz J, Gerloff C, Magnus T, Donzelli S. Choe CU, et al. Among authors: donzelli s. Antioxid Redox Signal. 2011 May 1;14(9):1699-711. doi: 10.1089/ars.2010.3852. Epub 2011 Mar 1. Antioxid Redox Signal. 2011. PMID: 21235347 Review.
185 results