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Methionine oxidation in α-synuclein inhibits its propensity for ordered secondary structure.
Ponzini E, De Palma A, Cerboni L, Natalello A, Rossi R, Moons R, Konijnenberg A, Narkiewicz J, Legname G, Sobott F, Mauri P, Santambrogio C, Grandori R. Ponzini E, et al. Among authors: sobott f. J Biol Chem. 2019 Apr 5;294(14):5657-5665. doi: 10.1074/jbc.RA118.001907. Epub 2019 Feb 12. J Biol Chem. 2019. PMID: 30755483 Free PMC article.
Cyclized NDGA modifies dynamic α-synuclein monomers preventing aggregation and toxicity.
Daniels MJ, Nourse JB Jr, Kim H, Sainati V, Schiavina M, Murrali MG, Pan B, Ferrie JJ, Haney CM, Moons R, Gould NS, Natalello A, Grandori R, Sobott F, Petersson EJ, Rhoades E, Pierattelli R, Felli I, Uversky VN, Caldwell KA, Caldwell GA, Krol ES, Ischiropoulos H. Daniels MJ, et al. Among authors: sobott f. Sci Rep. 2019 Feb 27;9(1):2937. doi: 10.1038/s41598-019-39480-z. Sci Rep. 2019. PMID: 30814575 Free PMC article.
Metal ions shape α-synuclein.
Moons R, Konijnenberg A, Mensch C, Van Elzen R, Johannessen C, Maudsley S, Lambeir AM, Sobott F. Moons R, et al. Among authors: sobott f. Sci Rep. 2020 Oct 1;10(1):16293. doi: 10.1038/s41598-020-73207-9. Sci Rep. 2020. PMID: 33004902 Free PMC article.
Decreased Water Mobility Contributes To Increased α-Synuclein Aggregation.
Stephens AD, Kölbel J, Moons R, Chung CW, Ruggiero MT, Mahmoudi N, Shmool TA, McCoy TM, Nietlispach D, Routh AF, Sobott F, Zeitler JA, Kaminski Schierle GS. Stephens AD, et al. Among authors: sobott f. Angew Chem Weinheim Bergstr Ger. 2023 Feb 6;135(7):e202212063. doi: 10.1002/ange.202212063. Epub 2023 Jan 12. Angew Chem Weinheim Bergstr Ger. 2023. PMID: 38516046 Free PMC article.
Brazilin Removes Toxic Alpha-Synuclein and Seeding Competent Assemblies from Parkinson Brain by Altering Conformational Equilibrium.
Nahass GR, Sun Y, Xu Y, Batchelor M, Reilly M, Benilova I, Kedia N, Spehar K, Sobott F, Sessions RB, Caughey B, Radford SE, Jat PS, Collinge J, Bieschke J. Nahass GR, et al. Among authors: sobott f. J Mol Biol. 2021 Apr 16;433(8):166878. doi: 10.1016/j.jmb.2021.166878. Epub 2021 Feb 19. J Mol Biol. 2021. PMID: 33610557 Free PMC article.
156 results