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Genetic architecture of 11 major psychiatric disorders at biobehavioral, functional genomic and molecular genetic levels of analysis.
Grotzinger AD, Mallard TT, Akingbuwa WA, Ip HF, Adams MJ, Lewis CM, McIntosh AM, Grove J, Dalsgaard S, Lesch KP, Strom N, Meier SM, Mattheisen M, Børglum AD, Mors O, Breen G; iPSYCH; Tourette Syndrome and Obsessive Compulsive Disorder Working Group of the Psychiatric Genetics Consortium; Bipolar Disorder Working Group of the Psychiatric Genetics Consortium; Major Depressive Disorder Working Group of the Psychiatric Genetics Consortium; Schizophrenia Working Group of the Psychiatric Genetics Consortium; Lee PH, Kendler KS, Smoller JW, Tucker-Drob EM, Nivard MG. Grotzinger AD, et al. Among authors: lesch kp. Nat Genet. 2022 May;54(5):548-559. doi: 10.1038/s41588-022-01057-4. Epub 2022 May 5. Nat Genet. 2022. PMID: 35513722 Free PMC article.
Functional variants of TSPAN8 are associated with bipolar disorder and schizophrenia.
Scholz CJ, Jacob CP, Buttenschon HN, Kittel-Schneider S, Boreatti-Hümmer A, Zimmer M, Walter U, Lesch KP, Mors O, Kneitz S, Deckert J, Reif A. Scholz CJ, et al. Among authors: lesch kp. Am J Med Genet B Neuropsychiatr Genet. 2010 Jun 5;153B(4):967-72. doi: 10.1002/ajmg.b.31057. Am J Med Genet B Neuropsychiatr Genet. 2010. PMID: 20052686
Polygenic transmission and complex neuro developmental network for attention deficit hyperactivity disorder: genome-wide association study of both common and rare variants.
Yang L, Neale BM, Liu L, Lee SH, Wray NR, Ji N, Li H, Qian Q, Wang D, Li J, Faraone SV, Wang Y; Psychiatric GWAS Consortium: ADHD Subgroup. Yang L, et al. Am J Med Genet B Neuropsychiatr Genet. 2013 Jul;162B(5):419-430. doi: 10.1002/ajmg.b.32169. Epub 2013 May 31. Am J Med Genet B Neuropsychiatr Genet. 2013. PMID: 23728934 Free PMC article.
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs.
Cross-Disorder Group of the Psychiatric Genomics Consortium; Lee SH, Ripke S, Neale BM, Faraone SV, Purcell SM, Perlis RH, Mowry BJ, Thapar A, Goddard ME, Witte JS, Absher D, Agartz I, Akil H, Amin F, Andreassen OA, Anjorin A, Anney R, Anttila V, Arking DE, Asherson P, Azevedo MH, Backlund L, Badner JA, Bailey AJ, Banaschewski T, Barchas JD, Barnes MR, Barrett TB, Bass N, Battaglia A, Bauer M, Bayés M, Bellivier F, Bergen SE, Berrettini W, Betancur C, Bettecken T, Biederman J, Binder EB, Black DW, Blackwood DH, Bloss CS, Boehnke M, Boomsma DI, Breen G, Breuer R, Bruggeman R, Cormican P, Buccola NG, Buitelaar JK, Bunney WE, Buxbaum JD, Byerley WF, Byrne EM, Caesar S, Cahn W, Cantor RM, Casas M, Chakravarti A, Chambert K, Choudhury K, Cichon S, Cloninger CR, Collier DA, Cook EH, Coon H, Cormand B, Corvin A, Coryell WH, Craig DW, Craig IW, Crosbie J, Cuccaro ML, Curtis D, Czamara D, Datta S, Dawson G, Day R, De Geus EJ, Degenhardt F, Djurovic S, Donohoe GJ, Doyle AE, Duan J, Dudbridge F, Duketis E, Ebstein RP, Edenberg HJ, Elia J, Ennis S, Etain B, Fanous A, Farmer AE, Ferrier IN, Flickinger M, Fombonne E, Foroud T, Frank J, Franke B, Fraser C, Freedman R, Freimer NB, Freitag CM, Fri… See abstract for full author list ➔ Cross-Disorder Group of the Psychiatric Genomics Consortium, et al. Among authors: lesch kp. Nat Genet. 2013 Sep;45(9):984-94. doi: 10.1038/ng.2711. Epub 2013 Aug 11. Nat Genet. 2013. PMID: 23933821 Free PMC article.
Joint analysis of psychiatric disorders increases accuracy of risk prediction for schizophrenia, bipolar disorder, and major depressive disorder.
Maier R, Moser G, Chen GB, Ripke S; Cross-Disorder Working Group of the Psychiatric Genomics Consortium; Coryell W, Potash JB, Scheftner WA, Shi J, Weissman MM, Hultman CM, Landén M, Levinson DF, Kendler KS, Smoller JW, Wray NR, Lee SH. Maier R, et al. Am J Hum Genet. 2015 Feb 5;96(2):283-94. doi: 10.1016/j.ajhg.2014.12.006. Epub 2015 Jan 29. Am J Hum Genet. 2015. PMID: 25640677 Free PMC article.
MicroRNA hsa-miR-4717-5p regulates RGS2 and may be a risk factor for anxiety-related traits.
Hommers L, Raab A, Bohl A, Weber H, Scholz CJ, Erhardt A, Binder E, Arolt V, Gerlach A, Gloster A, Kalisch R, Kircher T, Lonsdorf T, Ströhle A, Zwanzger P, Mattheisen M, Cichon S, Lesch KP, Domschke K, Reif A, Lohse MJ, Deckert J. Hommers L, et al. Among authors: lesch kp. Am J Med Genet B Neuropsychiatr Genet. 2015 Jun;168B(4):296-306. doi: 10.1002/ajmg.b.32312. Epub 2015 Apr 2. Am J Med Genet B Neuropsychiatr Genet. 2015. PMID: 25847876
Whole-Exome Sequencing Reveals Increased Burden of Rare Functional and Disruptive Variants in Candidate Risk Genes in Individuals With Persistent Attention-Deficit/Hyperactivity Disorder.
Demontis D, Lescai F, Børglum A, Glerup S, Østergaard SD, Mors O, Li Q, Liang J, Jiang H, Li Y, Wang J, Lesch KP, Reif A, Buitelaar JK, Franke B. Demontis D, et al. Among authors: lesch kp. J Am Acad Child Adolesc Psychiatry. 2016 Jun;55(6):521-3. doi: 10.1016/j.jaac.2016.03.009. J Am Acad Child Adolesc Psychiatry. 2016. PMID: 27238071 No abstract available.
680 results