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NSD1 mediates antagonism between SWI/SNF and polycomb complexes and is required for transcriptional activation upon EZH2 inhibition.
Drosos Y, Myers JA, Xu B, Mathias KM, Beane EC, Radko-Juettner S, Mobley RJ, Larsen ME, Piccioni F, Ma X, Low J, Hansen BS, Peters ST, Bhanu NV, Dhanda SK, Chen T, Upadhyaya SA, Pruett-Miller SM, Root DE, Garcia BA, Partridge JF, Roberts CWM. Drosos Y, et al. Among authors: roberts cwm. Mol Cell. 2022 Jul 7;82(13):2472-2489.e8. doi: 10.1016/j.molcel.2022.04.015. Epub 2022 May 9. Mol Cell. 2022. PMID: 35537449 Free PMC article.
SWI/SNF nucleosome remodellers and cancer.
Wilson BG, Roberts CW. Wilson BG, et al. Nat Rev Cancer. 2011 Jun 9;11(7):481-92. doi: 10.1038/nrc3068. Nat Rev Cancer. 2011. PMID: 21654818 Review.
Vulnerabilities of mutant SWI/SNF complexes in cancer.
Helming KC, Wang X, Roberts CWM. Helming KC, et al. Among authors: roberts cwm. Cancer Cell. 2014 Sep 8;26(3):309-317. doi: 10.1016/j.ccr.2014.07.018. Cancer Cell. 2014. PMID: 25203320 Free PMC article. Review.
Targeting EZH2 in cancer.
Kim KH, Roberts CW. Kim KH, et al. Nat Med. 2016 Feb;22(2):128-34. doi: 10.1038/nm.4036. Nat Med. 2016. PMID: 26845405 Free PMC article. Review.
Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting.
Aguirre AJ, Meyers RM, Weir BA, Vazquez F, Zhang CZ, Ben-David U, Cook A, Ha G, Harrington WF, Doshi MB, Kost-Alimova M, Gill S, Xu H, Ali LD, Jiang G, Pantel S, Lee Y, Goodale A, Cherniack AD, Oh C, Kryukov G, Cowley GS, Garraway LA, Stegmaier K, Roberts CW, Golub TR, Meyerson M, Root DE, Tsherniak A, Hahn WC. Aguirre AJ, et al. Cancer Discov. 2016 Aug;6(8):914-29. doi: 10.1158/2159-8290.CD-16-0154. Epub 2016 Jun 3. Cancer Discov. 2016. PMID: 27260156 Free PMC article.
SMARCB1-mediated SWI/SNF complex function is essential for enhancer regulation.
Wang X, Lee RS, Alver BH, Haswell JR, Wang S, Mieczkowski J, Drier Y, Gillespie SM, Archer TC, Wu JN, Tzvetkov EP, Troisi EC, Pomeroy SL, Biegel JA, Tolstorukov MY, Bernstein BE, Park PJ, Roberts CW. Wang X, et al. Nat Genet. 2017 Feb;49(2):289-295. doi: 10.1038/ng.3746. Epub 2016 Dec 12. Nat Genet. 2017. PMID: 27941797 Free PMC article.
84 results