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Single-cell eQTL models reveal dynamic T cell state dependence of disease loci.
Nathan A, Asgari S, Ishigaki K, Valencia C, Amariuta T, Luo Y, Beynor JI, Baglaenko Y, Suliman S, Price AL, Lecca L, Murray MB, Moody DB, Raychaudhuri S. Nathan A, et al. Among authors: beynor ji. Nature. 2022 Jun;606(7912):120-128. doi: 10.1038/s41586-022-04713-1. Epub 2022 May 11. Nature. 2022. PMID: 35545678 Free PMC article.
Multimodally profiling memory T cells from a tuberculosis cohort identifies cell state associations with demographics, environment and disease.
Nathan A, Beynor JI, Baglaenko Y, Suliman S, Ishigaki K, Asgari S, Huang CC, Luo Y, Zhang Z, Lopez K, Lindestam Arlehamn CS, Ernst JD, Jimenez J, Calderón RI, Lecca L, Van Rhijn I, Moody DB, Murray MB, Raychaudhuri S. Nathan A, et al. Among authors: beynor ji. Nat Immunol. 2021 Jun;22(6):781-793. doi: 10.1038/s41590-021-00933-1. Epub 2021 May 24. Nat Immunol. 2021. PMID: 34031617 Free PMC article.
Multimodal single-cell approaches shed light on T cell heterogeneity.
Nathan A, Baglaenko Y, Fonseka CY, Beynor JI, Raychaudhuri S. Nathan A, et al. Among authors: beynor ji. Curr Opin Immunol. 2019 Dec;61:17-25. doi: 10.1016/j.coi.2019.07.002. Epub 2019 Aug 17. Curr Opin Immunol. 2019. PMID: 31430664 Free PMC article. Review.
IFN-γ and TNF-α drive a CXCL10+ CCL2+ macrophage phenotype expanded in severe COVID-19 lungs and inflammatory diseases with tissue inflammation.
Zhang F, Mears JR, Shakib L, Beynor JI, Shanaj S, Korsunsky I, Nathan A; Accelerating Medicines Partnership Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) Consortium; Donlin LT, Raychaudhuri S. Zhang F, et al. Among authors: beynor ji. Genome Med. 2021 Apr 20;13(1):64. doi: 10.1186/s13073-021-00881-3. Genome Med. 2021. PMID: 33879239 Free PMC article.
IFN- γ and TNF- α drive a CXCL10 + CCL2 + macrophage phenotype expanded in severe COVID-19 and other diseases with tissue inflammation.
Zhang F, Mears JR, Shakib L, Beynor JI, Shanaj S, Korsunsky I, Nathan A; Accelerating Medicines Partnership Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) Consortium; Donlin LT, Raychaudhuri S. Zhang F, et al. Among authors: beynor ji. bioRxiv [Preprint]. 2020 Aug 5:2020.08.05.238360. doi: 10.1101/2020.08.05.238360. bioRxiv. 2020. PMID: 32793902 Free PMC article. Updated. Preprint.