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H3K9 methylation drives resistance to androgen receptor-antagonist therapy in prostate cancer.
Baratchian M, Tiwari R, Khalighi S, Chakravarthy A, Yuan W, Berk M, Li J, Guerinot A, de Bono J, Makarov V, Chan TA, Silverman RH, Stark GR, Varadan V, De Carvalho DD, Chakraborty AA, Sharifi N. Baratchian M, et al. Among authors: chakravarthy a. Proc Natl Acad Sci U S A. 2022 May 24;119(21):e2114324119. doi: 10.1073/pnas.2114324119. Epub 2022 May 18. Proc Natl Acad Sci U S A. 2022. PMID: 35584120 Free PMC article.
LSD1 Ablation Stimulates Anti-tumor Immunity and Enables Checkpoint Blockade.
Sheng W, LaFleur MW, Nguyen TH, Chen S, Chakravarthy A, Conway JR, Li Y, Chen H, Yang H, Hsu PH, Van Allen EM, Freeman GJ, De Carvalho DD, He HH, Sharpe AH, Shi Y. Sheng W, et al. Among authors: chakravarthy a. Cell. 2018 Jul 26;174(3):549-563.e19. doi: 10.1016/j.cell.2018.05.052. Epub 2018 Jun 21. Cell. 2018. PMID: 29937226 Free PMC article.
Epigenetic therapy in immune-oncology.
Jones PA, Ohtani H, Chakravarthy A, De Carvalho DD. Jones PA, et al. Among authors: chakravarthy a. Nat Rev Cancer. 2019 Mar;19(3):151-161. doi: 10.1038/s41568-019-0109-9. Nat Rev Cancer. 2019. PMID: 30723290 Review.
GCN2 drives macrophage and MDSC function and immunosuppression in the tumor microenvironment.
Halaby MJ, Hezaveh K, Lamorte S, Ciudad MT, Kloetgen A, MacLeod BL, Guo M, Chakravarthy A, Medina TDS, Ugel S, Tsirigos A, Bronte V, Munn DH, Pugh TJ, De Carvalho DD, Butler MO, Ohashi PS, Brooks DG, McGaha TL. Halaby MJ, et al. Among authors: chakravarthy a. Sci Immunol. 2019 Dec 13;4(42):eaax8189. doi: 10.1126/sciimmunol.aax8189. Sci Immunol. 2019. PMID: 31836669 Free PMC article.
Detection of renal cell carcinoma using plasma and urine cell-free DNA methylomes.
Nuzzo PV, Berchuck JE, Korthauer K, Spisak S, Nassar AH, Abou Alaiwi S, Chakravarthy A, Shen SY, Bakouny Z, Boccardo F, Steinharter J, Bouchard G, Curran CR, Pan W, Baca SC, Seo JH, Lee GM, Michaelson MD, Chang SL, Waikar SS, Sonpavde G, Irizarry RA, Pomerantz M, De Carvalho DD, Choueiri TK, Freedman ML. Nuzzo PV, et al. Among authors: chakravarthy a. Nat Med. 2020 Jul;26(7):1041-1043. doi: 10.1038/s41591-020-0933-1. Epub 2020 Jun 22. Nat Med. 2020. PMID: 32572266 Free PMC article.
An open-label, phase II multicohort study of an oral hypomethylating agent CC-486 and durvalumab in advanced solid tumors.
Taylor K, Loo Yau H, Chakravarthy A, Wang B, Shen SY, Ettayebi I, Ishak CA, Bedard PL, Abdul Razak A, R Hansen A, Spreafico A, Cescon D, Butler MO, Oza AM, Lheureux S, Stjepanovic N, Van As B, Boross-Harmer S, Wang L, Pugh TJ, Ohashi PS, Siu LL, De Carvalho DD. Taylor K, et al. Among authors: chakravarthy a. J Immunother Cancer. 2020 Aug;8(2):e000883. doi: 10.1136/jitc-2020-000883. J Immunother Cancer. 2020. PMID: 32753546 Free PMC article. Clinical Trial.
148 results