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The pore-forming subunit MCU of the mitochondrial Ca2+ uniporter is required for normal glucose-stimulated insulin secretion in vitro and in vivo in mice.
Georgiadou E, Haythorne E, Dickerson MT, Lopez-Noriega L, Pullen TJ, da Silva Xavier G, Davis SPX, Martinez-Sanchez A, Semplici F, Rizzuto R, McGinty JA, French PM, Cane MC, Jacobson DA, Leclerc I, Rutter GA. Georgiadou E, et al. Diabetologia. 2020 Jul;63(7):1368-1381. doi: 10.1007/s00125-020-05148-x. Epub 2020 Apr 29. Diabetologia. 2020. PMID: 32350566 Free PMC article.
Author Correction: Intravital imaging of islet Ca2+ dynamics reveals enhanced β cell connectivity after bariatric surgery in mice.
Akalestou E, Suba K, Lopez-Noriega L, Georgiadou E, Chabosseau P, Gallie A, Wretlind A, Legido-Quigley C, Leclerc I, Salem V, Rutter GA. Akalestou E, et al. Among authors: lopez noriega l. Nat Commun. 2021 Sep 20;12(1):5648. doi: 10.1038/s41467-021-25887-8. Nat Commun. 2021. PMID: 34545099 Free PMC article. No abstract available.
Opposing effects on regulated insulin secretion of acute vs chronic stimulation of AMP-activated protein kinase.
Nguyen-Tu MS, Harris J, Martinez-Sanchez A, Chabosseau P, Hu M, Georgiadou E, Pollard A, Otero P, Lopez-Noriega L, Leclerc I, Sakamoto K, Schmoll D, Smith DM, Carling D, Rutter GA. Nguyen-Tu MS, et al. Among authors: lopez noriega l. Diabetologia. 2022 Jun;65(6):997-1011. doi: 10.1007/s00125-022-05673-x. Epub 2022 Mar 16. Diabetologia. 2022. PMID: 35294578 Free PMC article.
Mitofusins Mfn1 and Mfn2 Are Required to Preserve Glucose- but Not Incretin-Stimulated β-Cell Connectivity and Insulin Secretion.
Georgiadou E, Muralidharan C, Martinez M, Chabosseau P, Akalestou E, Tomas A, Wern FYS, Stylianides T, Wretlind A, Legido-Quigley C, Jones B, Lopez-Noriega L, Xu Y, Gu G, Alsabeeh N, Cruciani-Guglielmacci C, Magnan C, Ibberson M, Leclerc I, Ali Y, Soleimanpour SA, Linnemann AK, Rodriguez TA, Rutter GA. Georgiadou E, et al. Among authors: lopez noriega l. Diabetes. 2022 Jul 1;71(7):1472-1489. doi: 10.2337/db21-0800. Diabetes. 2022. PMID: 35472764 Free PMC article.
Identification of biomarkers for glycaemic deterioration in type 2 diabetes.
Slieker RC, Donnelly LA, Akalestou E, Lopez-Noriega L, Melhem R, Güneş A, Abou Azar F, Efanov A, Georgiadou E, Muniangi-Muhitu H, Sheikh M, Giordano GN, Åkerlund M, Ahlqvist E, Ali A, Banasik K, Brunak S, Barovic M, Bouland GA, Burdet F, Canouil M, Dragan I, Elders PJM, Fernandez C, Festa A, Fitipaldi H, Froguel P, Gudmundsdottir V, Gudnason V, Gerl MJ, van der Heijden AA, Jennings LL, Hansen MK, Kim M, Leclerc I, Klose C, Kuznetsov D, Mansour Aly D, Mehl F, Marek D, Melander O, Niknejad A, Ottosson F, Pavo I, Duffin K, Syed SK, Shaw JL, Cabrera O, Pullen TJ, Simons K, Solimena M, Suvitaival T, Wretlind A, Rossing P, Lyssenko V, Legido Quigley C, Groop L, Thorens B, Franks PW, Lim GE, Estall J, Ibberson M, Beulens JWJ, 't Hart LM, Pearson ER, Rutter GA. Slieker RC, et al. Among authors: lopez noriega l. Nat Commun. 2023 May 3;14(1):2533. doi: 10.1038/s41467-023-38148-7. Nat Commun. 2023. PMID: 37137910 Free PMC article.
PAX4 preserves endoplasmic reticulum integrity preventing beta cell degeneration in a mouse model of type 1 diabetes mellitus.
Mellado-Gil JM, Jiménez-Moreno CM, Martin-Montalvo A, Alvarez-Mercado AI, Fuente-Martin E, Cobo-Vuilleumier N, Lorenzo PI, Bru-Tari E, Herrera-Gómez Ide G, López-Noriega L, Pérez-Florido J, Santoyo-López J, Spyrantis A, Meda P, Boehm BO, Quesada I, Gauthier BR. Mellado-Gil JM, et al. Diabetologia. 2016 Apr;59(4):755-65. doi: 10.1007/s00125-016-3864-0. Epub 2016 Jan 26. Diabetologia. 2016. PMID: 26813254 Free PMC article.
23 results