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Safety, pharmacokinetics and target engagement of novel RIPK1 inhibitor SAR443060 (DNL747) for neurodegenerative disorders: Randomized, placebo-controlled, double-blind phase I/Ib studies in healthy subjects and patients.
Vissers MFJM, Heuberger JAAC, Groeneveld GJ, Oude Nijhuis J, De Deyn PP, Hadi S, Harris J, Tsai RM, Cruz-Herranz A, Huang F, Tong V, Erickson R, Zhu Y, Scearce-Levie K, Hsiao-Nakamoto J, Tang X, Chang M, Fox BM, Estrada AA, Pomponio RJ, Alonso-Alonso M, Zilberstein M, Atassi N, Troyer MD, Ho C. Vissers MFJM, et al. Among authors: de deyn pp. Clin Transl Sci. 2022 Aug;15(8):2010-2023. doi: 10.1111/cts.13317. Epub 2022 Jun 1. Clin Transl Sci. 2022. PMID: 35649245 Free PMC article. Clinical Trial.
Tolerability of extended-release quetiapine fumarate compared with immediate-release quetiapine fumarate in older patients with Alzheimer's disease with symptoms of psychosis and/or agitation: a randomised, double-blind, parallel-group study.
De Deyn PP, Eriksson H, Svensson H; Study 115 investigators. De Deyn PP, et al. Int J Geriatr Psychiatry. 2012 Mar;27(3):296-304. doi: 10.1002/gps.2720. Epub 2011 Apr 27. Int J Geriatr Psychiatry. 2012. PMID: 21538537 Clinical Trial.
Drug discovery in dementia: the role of rodent models.
Van Dam D, De Deyn PP. Van Dam D, et al. Among authors: de deyn pp. Nat Rev Drug Discov. 2006 Nov;5(11):956-70. doi: 10.1038/nrd2075. Nat Rev Drug Discov. 2006. PMID: 17080031 Review.
792 results