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32 results

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Page 1
Safety, pharmacokinetics and target engagement of novel RIPK1 inhibitor SAR443060 (DNL747) for neurodegenerative disorders: Randomized, placebo-controlled, double-blind phase I/Ib studies in healthy subjects and patients.
Vissers MFJM, Heuberger JAAC, Groeneveld GJ, Oude Nijhuis J, De Deyn PP, Hadi S, Harris J, Tsai RM, Cruz-Herranz A, Huang F, Tong V, Erickson R, Zhu Y, Scearce-Levie K, Hsiao-Nakamoto J, Tang X, Chang M, Fox BM, Estrada AA, Pomponio RJ, Alonso-Alonso M, Zilberstein M, Atassi N, Troyer MD, Ho C. Vissers MFJM, et al. Among authors: heuberger jaac. Clin Transl Sci. 2022 Aug;15(8):2010-2023. doi: 10.1111/cts.13317. Epub 2022 Jun 1. Clin Transl Sci. 2022. PMID: 35649245 Free PMC article. Clinical Trial.
Pharmacokinetic Modeling and Dose Selection in a Randomized, Double-Blind, Placebo-Controlled Trial of a Human Recombinant Alkaline Phosphatase in Healthy Volunteers.
Peters E, Heuberger JAAC, Tiessen R, van Elsas A, Masereeuw R, Arend J, Stevens J, Pickkers P. Peters E, et al. Among authors: heuberger jaac. Clin Pharmacokinet. 2016 Oct;55(10):1227-1237. doi: 10.1007/s40262-016-0399-y. Clin Pharmacokinet. 2016. PMID: 27147514 Free PMC article. Clinical Trial.
Acute Effects of Riluzole and Retigabine on Axonal Excitability in Patients With Amyotrophic Lateral Sclerosis: A Randomized, Double-Blind, Placebo-Controlled, Crossover Trial.
Kovalchuk MO, Heuberger JAAC, Sleutjes BTHM, Ziagkos D, van den Berg LH, Ferguson TA, Franssen H, Groeneveld GJ. Kovalchuk MO, et al. Among authors: heuberger jaac. Clin Pharmacol Ther. 2018 Dec;104(6):1136-1145. doi: 10.1002/cpt.1096. Epub 2018 Jun 19. Clin Pharmacol Ther. 2018. PMID: 29672831 Clinical Trial.
DNL104, a Centrally Penetrant RIPK1 Inhibitor, Inhibits RIP1 Kinase Phosphorylation in a Randomized Phase I Ascending Dose Study in Healthy Volunteers.
Grievink HW, Heuberger JAAC, Huang F, Chaudhary R, Birkhoff WAJ, Tonn GR, Mosesova S, Erickson R, Moerland M, Haddick PCG, Scearce-Levie K, Ho C, Groeneveld GJ. Grievink HW, et al. Among authors: heuberger jaac. Clin Pharmacol Ther. 2020 Feb;107(2):406-414. doi: 10.1002/cpt.1615. Epub 2019 Sep 25. Clin Pharmacol Ther. 2020. PMID: 31437302 Clinical Trial.
Transcranial magnetic stimulation as biomarker of excitability in drug development: A randomized, double-blind, placebo-controlled, cross-over study.
Ruijs TQ, Heuberger JAAC, de Goede AA, Ziagkos D, Otto ME, Doll RJ, van Putten MJAM, Groeneveld GJ. Ruijs TQ, et al. Among authors: heuberger jaac. Br J Clin Pharmacol. 2022 Jun;88(6):2926-2937. doi: 10.1111/bcp.15232. Epub 2022 Feb 3. Br J Clin Pharmacol. 2022. PMID: 35028950 Free PMC article. Clinical Trial.
Effect of sustained high buprenorphine plasma concentrations on fentanyl-induced respiratory depression: A placebo-controlled crossover study in healthy volunteers and opioid-tolerant patients.
Moss LM, Algera MH, Dobbins R, Gray F, Strafford S, Heath A, van Velzen M, Heuberger JAAC, Niesters M, Olofsen E, Laffont CM, Dahan A, Groeneveld GJ. Moss LM, et al. Among authors: heuberger jaac. PLoS One. 2022 Jan 27;17(1):e0256752. doi: 10.1371/journal.pone.0256752. eCollection 2022. PLoS One. 2022. PMID: 35085249 Free PMC article. Clinical Trial.
32 results