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A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation.
Vujkovic M, Ramdas S, Lorenz KM, Guo X, Darlay R, Cordell HJ, He J, Gindin Y, Chung C, Myers RP, Schneider CV, Park J, Lee KM, Serper M, Carr RM, Kaplan DE, Haas ME, MacLean MT, Witschey WR, Zhu X, Tcheandjieu C, Kember RL, Kranzler HR, Verma A, Giri A, Klarin DM, Sun YV, Huang J, Huffman JE, Creasy KT, Hand NJ, Liu CT, Long MT, Yao J, Budoff M, Tan J, Li X, Lin HJ, Chen YI, Taylor KD, Chang RK, Krauss RM, Vilarinho S, Brancale J, Nielsen JB, Locke AE, Jones MB, Verweij N, Baras A, Reddy KR, Neuschwander-Tetri BA, Schwimmer JB, Sanyal AJ, Chalasani N, Ryan KA, Mitchell BD, Gill D, Wells AD, Manduchi E, Saiman Y, Mahmud N, Miller DR, Reaven PD, Phillips LS, Muralidhar S, DuVall SL, Lee JS, Assimes TL, Pyarajan S, Cho K, Edwards TL, Damrauer SM, Wilson PW, Gaziano JM, O'Donnell CJ, Khera AV, Grant SFA, Brown CD, Tsao PS, Saleheen D, Lotta LA, Bastarache L, Anstee QM, Daly AK, Meigs JB, Rotter JI, Lynch JA; Regeneron Genetics Center; Geisinger-Regeneron DiscovEHR Collaboration; EPoS Consortium; VA Million Veteran Program; Rader DJ, Voight BF, Chang KM. Vujkovic M, et al. Among authors: witschey wr. Nat Genet. 2022 Jun;54(6):761-771. doi: 10.1038/s41588-022-01078-z. Epub 2022 Jun 2. Nat Genet. 2022. PMID: 35654975 Free PMC article.
Quantification of abdominal fat from computed tomography using deep learning and its association with electronic health records in an academic biobank.
MacLean MT, Jehangir Q, Vujkovic M, Ko YA, Litt H, Borthakur A, Sagreiya H, Rosen M, Mankoff DA, Schnall MD, Shou H, Chirinos J, Damrauer SM, Torigian DA, Carr R, Rader DJ, Witschey WR. MacLean MT, et al. Among authors: witschey wr. J Am Med Inform Assoc. 2021 Jun 12;28(6):1178-1187. doi: 10.1093/jamia/ocaa342. J Am Med Inform Assoc. 2021. PMID: 33576413 Free PMC article.
Exome-wide association analysis of CT imaging-derived hepatic fat in a medical biobank.
Park J, MacLean MT, Lucas AM, Torigian DA, Schneider CV, Cherlin T, Xiao B, Miller JE, Bradford Y, Judy RL; Regeneron Genetics Center; Verma A, Damrauer SM, Ritchie MD, Witschey WR, Rader DJ. Park J, et al. Among authors: witschey wr. Cell Rep Med. 2022 Dec 20;3(12):100855. doi: 10.1016/j.xcrm.2022.100855. Epub 2022 Dec 12. Cell Rep Med. 2022. PMID: 36513072 Free PMC article.
Clinical correlates of CT imaging-derived phenotypes among lean and overweight patients with hepatic steatosis.
Song I, Thompson EW, Verma A, MacLean MT, Duda J, Elahi A, Tran R, Raghupathy P, Swago S, Hazim M, Bhattaru A, Schneider C, Vujkovic M, Torigian DA, Kahn CE, Gee JC, Borthakur A, Kripke CM, Carson CC, Carr R, Jehangir Q, Ko YA, Litt H, Rosen M, Mankoff DA, Schnall MD, Shou H, Chirinos J, Damrauer SM, Serper M, Chen J, Rader DJ; Penn Medicine BioBank; Witschey WRT, Sagreiya H. Song I, et al. Among authors: witschey wrt. Sci Rep. 2024 Jan 2;14(1):53. doi: 10.1038/s41598-023-49470-x. Sci Rep. 2024. PMID: 38167550 Free PMC article.
Deep learning approach for automated segmentation of myocardium using bone scintigraphy single-photon emission computed tomography/computed tomography in patients with suspected cardiac amyloidosis.
Bhattaru A, Rojulpote C, Vidula M, Duda J, Maclean MT, Swago S, Thompson E, Gee J, Pieretti J, Drachman B, Cohen A, Dorbala S, Bravo PE, Witschey WR. Bhattaru A, et al. Among authors: witschey wr. J Nucl Cardiol. 2024 Mar;33:101809. doi: 10.1016/j.nuclcard.2024.101809. Epub 2024 Feb 1. J Nucl Cardiol. 2024. PMID: 38307160
Integrated Regional Cardiac Hemodynamic Imaging and RNA Sequencing Reveal Corresponding Heterogeneity of Ventricular Wall Shear Stress and Endocardial Transcriptome.
McCormick ME, Manduchi E, Witschey WR, Gorman RC, Gorman JH 3rd, Jiang YZ, Stoeckert CJ Jr, Barker AJ, Markl M, Davies PF. McCormick ME, et al. Among authors: witschey wr. J Am Heart Assoc. 2016 Apr 18;5(4):e003170. doi: 10.1161/JAHA.115.003170. J Am Heart Assoc. 2016. PMID: 27091183 Free PMC article.
91 results