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Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates.
Nat Biotechnol. 2022 Oct;40(10):1500-1508. doi: 10.1038/s41587-022-01334-x. Epub 2022 Jun 2.
Nat Biotechnol. 2022.
PMID: 35654979
Impact of Serum Proteins on the Uptake and RNAi Activity of GalNAc-Conjugated siRNAs.
Agarwal S, Allard R, Darcy J, Chigas S, Gu Y, Nguyen T, Bond S, Chong S, Wu JT, Janas MM.
Agarwal S, et al. Among authors: chigas s.
Nucleic Acid Ther. 2021 Aug;31(4):309-315. doi: 10.1089/nat.2020.0919. Epub 2021 Apr 15.
Nucleic Acid Ther. 2021.
PMID: 33861634
Free PMC article.
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Evaluation of electrophoretic mobility shift assay as a method to determine plasma protein binding of siRNA.
Rocca C, Dennin S, Gu Y, Kim J, Chigas S, Najarian D, Chong S, Gutierrez S, Butler J, Charisse K, Robbie G, Xu Y, Brown K.
Rocca C, et al. Among authors: chigas s.
Bioanalysis. 2019 Nov;11(21):1927-1939. doi: 10.4155/bio-2019-0151.
Bioanalysis. 2019.
PMID: 31829053
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