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MacroH2As regulate enhancer-promoter contacts affecting enhancer activity and sensitivity to inflammatory cytokines.
Corujo D, Malinverni R, Carrillo-Reixach J, Meers O, Garcia-Jaraquemada A, Le Pannérer MM, Valero V, Pérez A, Del Río-Álvarez Á, Royo L, Pérez-González B, Raurell H, Acemel RD, Santos-Pereira JM, Garrido-Pontnou M, Gómez-Skarmeta JL, Pasquali L, Manyé J, Armengol C, Buschbeck M. Corujo D, et al. Among authors: gomez skarmeta jl. Cell Rep. 2022 Jun 21;39(12):110988. doi: 10.1016/j.celrep.2022.110988. Cell Rep. 2022. PMID: 35732123 Free article.
Obesity-associated variants within FTO form long-range functional connections with IRX3.
Smemo S, Tena JJ, Kim KH, Gamazon ER, Sakabe NJ, Gómez-Marín C, Aneas I, Credidio FL, Sobreira DR, Wasserman NF, Lee JH, Puviindran V, Tam D, Shen M, Son JE, Vakili NA, Sung HK, Naranjo S, Acemel RD, Manzanares M, Nagy A, Cox NJ, Hui CC, Gomez-Skarmeta JL, Nóbrega MA. Smemo S, et al. Nature. 2014 Mar 20;507(7492):371-5. doi: 10.1038/nature13138. Epub 2014 Mar 12. Nature. 2014. PMID: 24646999 Free PMC article.
A polymorphic enhancer near GREM1 influences bowel cancer risk through differential CDX2 and TCF7L2 binding.
Lewis A, Freeman-Mills L, de la Calle-Mustienes E, Giráldez-Pérez RM, Davis H, Jaeger E, Becker M, Hubner NC, Nguyen LN, Zeron-Medina J, Bond G, Stunnenberg HG, Carvajal JJ, Gomez-Skarmeta JL, Leedham S, Tomlinson I. Lewis A, et al. Cell Rep. 2014 Aug 21;8(4):983-90. doi: 10.1016/j.celrep.2014.07.020. Epub 2014 Aug 14. Cell Rep. 2014. PMID: 25131200 Free PMC article.
TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors.
Cebola I, Rodríguez-Seguí SA, Cho CH, Bessa J, Rovira M, Luengo M, Chhatriwala M, Berry A, Ponsa-Cobas J, Maestro MA, Jennings RE, Pasquali L, Morán I, Castro N, Hanley NA, Gomez-Skarmeta JL, Vallier L, Ferrer J. Cebola I, et al. Nat Cell Biol. 2015 May;17(5):615-626. doi: 10.1038/ncb3160. Epub 2015 Apr 27. Nat Cell Biol. 2015. PMID: 25915126 Free PMC article.
Evolutionary comparison reveals that diverging CTCF sites are signatures of ancestral topological associating domains borders.
Gómez-Marín C, Tena JJ, Acemel RD, López-Mayorga M, Naranjo S, de la Calle-Mustienes E, Maeso I, Beccari L, Aneas I, Vielmas E, Bovolenta P, Nobrega MA, Carvajal J, Gómez-Skarmeta JL. Gómez-Marín C, et al. Proc Natl Acad Sci U S A. 2015 Jun 16;112(24):7542-7. doi: 10.1073/pnas.1505463112. Epub 2015 Jun 1. Proc Natl Acad Sci U S A. 2015. PMID: 26034287 Free PMC article.
A single three-dimensional chromatin compartment in amphioxus indicates a stepwise evolution of vertebrate Hox bimodal regulation.
Acemel RD, Tena JJ, Irastorza-Azcarate I, Marlétaz F, Gómez-Marín C, de la Calle-Mustienes E, Bertrand S, Diaz SG, Aldea D, Aury JM, Mangenot S, Holland PW, Devos DP, Maeso I, Escrivá H, Gómez-Skarmeta JL. Acemel RD, et al. Nat Genet. 2016 Mar;48(3):336-41. doi: 10.1038/ng.3497. Epub 2016 Feb 1. Nat Genet. 2016. PMID: 26829752
Cis-regulatory landscapes in development and evolution.
Maeso I, Acemel RD, Gómez-Skarmeta JL. Maeso I, et al. Curr Opin Genet Dev. 2017 Apr;43:17-22. doi: 10.1016/j.gde.2016.10.004. Epub 2016 Nov 11. Curr Opin Genet Dev. 2017. PMID: 27842294 Review.
142 results