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Conjunctival epithelial cells resist productive SARS-CoV-2 infection.
Jackson RM, Hatton CF, Spegarova JS, Georgiou M, Collin J, Stephenson E, Verdon B, Haq IJ, Hussain R, Coxhead JM, Mudhar HS, Wagner B, Hasoon M, Davey T, Rooney P, Khan CMA, Ward C, Brodlie M, Haniffa M, Hambleton S, Armstrong L, Figueiredo F, Queen R, Duncan CJA, Lako M. Jackson RM, et al. Among authors: hatton cf. Stem Cell Reports. 2022 Jul 12;17(7):1699-1713. doi: 10.1016/j.stemcr.2022.05.017. Epub 2022 Jun 23. Stem Cell Reports. 2022. PMID: 35750043 Free PMC article.
A Novel Case of Homozygous Interferon Alpha/Beta Receptor Alpha Chain (IFNAR1) Deficiency With Hemophagocytic Lymphohistiocytosis.
Gothe F, Hatton CF, Truong L, Klimova Z, Kanderova V, Fejtkova M, Grainger A, Bigley V, Perthen J, Mitra D, Janda A, Fronkova E, Moravcikova D, Hambleton S, Duncan CJA. Gothe F, et al. Among authors: hatton cf. Clin Infect Dis. 2022 Jan 7;74(1):136-139. doi: 10.1093/cid/ciaa1790. Clin Infect Dis. 2022. PMID: 33252644 Free PMC article.
Development of a physiological model of human middle ear epithelium.
Mather MW, Verdon B, Botting RA, Engelbert J, Delpiano L, Xu X, Hatton C, Davey T, Lisgo S, Yates P, Dawe N, Bingle CD, Haniffa M, Powell J, Ward C. Mather MW, et al. Laryngoscope Investig Otolaryngol. 2021 Sep 18;6(5):1167-1174. doi: 10.1002/lio2.661. eCollection 2021 Oct. Laryngoscope Investig Otolaryngol. 2021. PMID: 34667862 Free PMC article.
Delayed induction of type I and III interferons mediates nasal epithelial cell permissiveness to SARS-CoV-2.
Hatton CF, Botting RA, Dueñas ME, Haq IJ, Verdon B, Thompson BJ, Spegarova JS, Gothe F, Stephenson E, Gardner AI, Murphy S, Scott J, Garnett JP, Carrie S, Powell J, Khan CMA, Huang L, Hussain R, Coxhead J, Davey T, Simpson AJ, Haniffa M, Hambleton S, Brodlie M, Ward C, Trost M, Reynolds G, Duncan CJA. Hatton CF, et al. Nat Commun. 2021 Dec 7;12(1):7092. doi: 10.1038/s41467-021-27318-0. Nat Commun. 2021. PMID: 34876592 Free PMC article.
Aberrant inflammatory responses to type I interferon in STAT2 or IRF9 deficiency.
Gothe F, Stremenova Spegarova J, Hatton CF, Griffin H, Sargent T, Cowley SA, James W, Roppelt A, Shcherbina A, Hauck F, Reyburn HT, Duncan CJA, Hambleton S. Gothe F, et al. Among authors: hatton cf. J Allergy Clin Immunol. 2022 Oct;150(4):955-964.e16. doi: 10.1016/j.jaci.2022.01.026. Epub 2022 Feb 17. J Allergy Clin Immunol. 2022. PMID: 35182547 Free article.
Life-threatening viral disease in a novel form of autosomal recessive IFNAR2 deficiency in the Arctic.
Duncan CJA, Skouboe MK, Howarth S, Hollensen AK, Chen R, Børresen ML, Thompson BJ, Stremenova Spegarova J, Hatton CF, Stæger FF, Andersen MK, Whittaker J, Paludan SR, Jørgensen SE, Thomsen MK, Mikkelsen JG, Heilmann C, Buhas D, Øbro NF, Bay JT, Marquart HV, de la Morena MT, Klejka JA, Hirschfeld M, Borgwardt L, Forss I, Masmas T, Poulsen A, Noya F, Rouleau G, Hansen T, Zhou S, Albrechtsen A, Alizadehfar R, Allenspach EJ, Hambleton S, Mogensen TH. Duncan CJA, et al. Among authors: hatton cf. J Exp Med. 2022 Jun 6;219(6):e20212427. doi: 10.1084/jem.20212427. Epub 2022 Apr 20. J Exp Med. 2022. PMID: 35442417 Free PMC article.