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A Targetable Myeloid Inflammatory State Governs Disease Recurrence in Clear-Cell Renal Cell Carcinoma.
Rappold PM, Vuong L, Leibold J, Chakiryan NH, Curry M, Kuo F, Sabio E, Jiang H, Nixon BG, Liu M, Berglund AE, Silagy AW, Mascareno EA, Golkaram M, Marker M, Reising A, Savchenko A, Millholland J, Chen YB, Russo P, Coleman J, Reznik E, Manley BJ, Ostrovnaya I, Makarov V, DiNatale RG, Blum KA, Ma X, Chowell D, Li MO, Solit DB, Lowe SW, Chan TA, Motzer RJ, Voss MH, Hakimi AA. Rappold PM, et al. Among authors: chakiryan nh. Cancer Discov. 2022 Oct 5;12(10):2308-2329. doi: 10.1158/2159-8290.CD-21-0925. Cancer Discov. 2022. PMID: 35758895 Free PMC article. Clinical Trial.
Reconnaissance of tumor immune microenvironment spatial heterogeneity in metastatic renal cell carcinoma and correlation with immunotherapy response.
Hajiran A, Chakiryan N, Aydin AM, Zemp L, Nguyen J, Laborde JM, Chahoud J, Spiess PE, Zaman S, Falasiri S, Fournier M, Teer JK, Dhillon J, McCarthy S, Moran-Segura C, Katende EN, Sexton WJ, Koomen JM, Mulé J, Kim Y, Manley B. Hajiran A, et al. Clin Exp Immunol. 2021 Apr;204(1):96-106. doi: 10.1111/cei.13567. Epub 2021 Feb 9. Clin Exp Immunol. 2021. PMID: 33346915 Free PMC article.
Spatial clustering of CD68+ tumor associated macrophages with tumor cells is associated with worse overall survival in metastatic clear cell renal cell carcinoma.
Chakiryan NH, Kimmel GJ, Kim Y, Hajiran A, Aydin AM, Zemp L, Katende E, Nguyen J, Lopez-Blanco N, Chahoud J, Spiess PE, Fournier M, Dhillon J, Wang L, Moran-Segura C, El-Kenawi A, Mulé J, Altrock PM, Manley BJ. Chakiryan NH, et al. PLoS One. 2021 Apr 21;16(4):e0245415. doi: 10.1371/journal.pone.0245415. eCollection 2021. PLoS One. 2021. PMID: 33882057 Free PMC article.
Correlating Immune Cell Infiltration Patterns with Recurrent Somatic Mutations in Advanced Clear Cell Renal Cell Carcinoma.
Chakiryan NH, Hajiran A, Kim Y, Aydin AM, Zemp L, Katende E, Nguyen J, Fan W, Cheng CH, Lopez-Blanco N, Chahoud J, Spiess PE, Fournier M, Dhillon J, Wang L, Moran-Segura C, Mulé J, Du D, Yoder SJ, Berglund A, Teer JK, Manley BJ. Chakiryan NH, et al. Eur Urol Focus. 2022 May;8(3):784-793. doi: 10.1016/j.euf.2021.04.014. Epub 2021 May 11. Eur Urol Focus. 2022. PMID: 33994165 Free PMC article.
Real-World Survival Outcomes Associated With First-Line Immunotherapy, Targeted Therapy, and Combination Therapy for Metastatic Clear Cell Renal Cell Carcinoma.
Chakiryan NH, Jiang DD, Gillis KA, Green E, Hajiran A, Hugar L, Zemp L, Zhang J, Jain RK, Chahoud J, Spiess PE, Sexton W, Gilbert SM, Manley BJ. Chakiryan NH, et al. JAMA Netw Open. 2021 May 3;4(5):e2111329. doi: 10.1001/jamanetworkopen.2021.11329. JAMA Netw Open. 2021. PMID: 34032854 Free PMC article.
Geospatial Cellular Distribution of Cancer-Associated Fibroblasts Significantly Impacts Clinical Outcomes in Metastatic Clear Cell Renal Cell Carcinoma.
Chakiryan NH, Kimmel GJ, Kim Y, Johnson JO, Clark N, Hajiran A, Chang A, Aydin AM, Zemp L, Katende E, Chahoud J, Ferrall-Fairbanks MC, Spiess PE, Francis N, Fournier M, Dhillon J, Park JY, Wang L, Mulé JJ, Altrock PM, Manley BJ. Chakiryan NH, et al. Cancers (Basel). 2021 Jul 26;13(15):3743. doi: 10.3390/cancers13153743. Cancers (Basel). 2021. PMID: 34359645 Free PMC article.
42 results