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Single-cell and bulk transcriptome sequencing identifies two epithelial tumor cell states and refines the consensus molecular classification of colorectal cancer.
Joanito I, Wirapati P, Zhao N, Nawaz Z, Yeo G, Lee F, Eng CLP, Macalinao DC, Kahraman M, Srinivasan H, Lakshmanan V, Verbandt S, Tsantoulis P, Gunn N, Venkatesh PN, Poh ZW, Nahar R, Oh HLJ, Loo JM, Chia S, Cheow LF, Cheruba E, Wong MT, Kua L, Chua C, Nguyen A, Golovan J, Gan A, Lim WJ, Guo YA, Yap CK, Tay B, Hong Y, Chong DQ, Chok AY, Park WY, Han S, Chang MH, Seow-En I, Fu C, Mathew R, Toh EL, Hong LZ, Skanderup AJ, DasGupta R, Ong CJ, Lim KH, Tan EKW, Koo SL, Leow WQ, Tejpar S, Prabhakar S, Tan IB. Joanito I, et al. Among authors: chia s. Nat Genet. 2022 Jul;54(7):963-975. doi: 10.1038/s41588-022-01100-4. Epub 2022 Jun 30. Nat Genet. 2022. PMID: 35773407 Free PMC article.
Phenotype-driven precision oncology as a guide for clinical decisions one patient at a time.
Chia S, Low JL, Zhang X, Kwang XL, Chong FT, Sharma A, Bertrand D, Toh SY, Leong HS, Thangavelu MT, Hwang JSG, Lim KH, Skanthakumar T, Tan HK, Su Y, Hui Choo S, Hentze H, Tan IBH, Lezhava A, Tan P, Tan DSW, Periyasamy G, Koh JLY, Gopalakrishna Iyer N, DasGupta R. Chia S, et al. Nat Commun. 2017 Sep 5;8(1):435. doi: 10.1038/s41467-017-00451-5. Nat Commun. 2017. PMID: 28874669 Free PMC article.
Longitudinal single-cell RNA sequencing of patient-derived primary cells reveals drug-induced infidelity in stem cell hierarchy.
Sharma A, Cao EY, Kumar V, Zhang X, Leong HS, Wong AML, Ramakrishnan N, Hakimullah M, Teo HMV, Chong FT, Chia S, Thangavelu MT, Kwang XL, Gupta R, Clark JR, Periyasamy G, Iyer NG, DasGupta R. Sharma A, et al. Among authors: chia s. Nat Commun. 2018 Nov 22;9(1):4931. doi: 10.1038/s41467-018-07261-3. Nat Commun. 2018. PMID: 30467425 Free PMC article.
A comparative study of tumour-on-chip models with patient-derived xenografts for predicting chemotherapy efficacy in colorectal cancer patients.
Ong LJY, Chia S, Wong SQR, Zhang X, Chua H, Loo JM, Chua WY, Chua C, Tan E, Hentze H, Tan IB, DasGupta R, Toh YC. Ong LJY, et al. Among authors: chia s. Front Bioeng Biotechnol. 2022 Aug 16;10:952726. doi: 10.3389/fbioe.2022.952726. eCollection 2022. Front Bioeng Biotechnol. 2022. PMID: 36147524 Free PMC article.
Evolution of precision oncology-guided treatment paradigms.
DasGupta R, Yap A, Yaqing EY, Chia S. DasGupta R, et al. Among authors: chia s. WIREs Mech Dis. 2023 Jan;15(1):e1585. doi: 10.1002/wsbm.1585. Epub 2022 Sep 27. WIREs Mech Dis. 2023. PMID: 36168283 Review.
Single-cell analysis of EphA clustering phenotypes to probe cancer cell heterogeneity.
Ravasio A, Myaing MZ, Chia S, Arora A, Sathe A, Cao EY, Bertocchi C, Sharma A, Arasi B, Chung VY, Greene AC, Tan TZ, Chen Z, Ong HT, Iyer NG, Huang RY, DasGupta R, Groves JT, Viasnoff V. Ravasio A, et al. Among authors: chia s. Commun Biol. 2020 Aug 6;3(1):429. doi: 10.1038/s42003-020-01136-4. Commun Biol. 2020. PMID: 32764731 Free PMC article.
886 results