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Determining target engagement in living systems.
Simon GM, Niphakis MJ, Cravatt BF. Simon GM, et al. Among authors: cravatt bf. Nat Chem Biol. 2013 Apr;9(4):200-5. doi: 10.1038/nchembio.1211. Nat Chem Biol. 2013. PMID: 23508173 Free PMC article.
Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer.
Bar-Peled L, Kemper EK, Suciu RM, Vinogradova EV, Backus KM, Horning BD, Paul TA, Ichu TA, Svensson RU, Olucha J, Chang MW, Kok BP, Zhu Z, Ihle NT, Dix MM, Jiang P, Hayward MM, Saez E, Shaw RJ, Cravatt BF. Bar-Peled L, et al. Among authors: cravatt bf. Cell. 2017 Oct 19;171(3):696-709.e23. doi: 10.1016/j.cell.2017.08.051. Epub 2017 Sep 28. Cell. 2017. PMID: 28965760 Free PMC article.
Pharmacological convergence reveals a lipid pathway that regulates C. elegans lifespan.
Chen AL, Lum KM, Lara-Gonzalez P, Ogasawara D, Cognetta AB 3rd, To A, Parsons WH, Simon GM, Desai A, Petrascheck M, Bar-Peled L, Cravatt BF. Chen AL, et al. Among authors: cravatt bf. Nat Chem Biol. 2019 May;15(5):453-462. doi: 10.1038/s41589-019-0243-4. Epub 2019 Mar 25. Nat Chem Biol. 2019. PMID: 30911178 Free PMC article.
A masked zinger to block GPX4.
Kathman SG, Cravatt BF. Kathman SG, et al. Among authors: cravatt bf. Nat Chem Biol. 2020 May;16(5):482-483. doi: 10.1038/s41589-020-0511-3. Nat Chem Biol. 2020. PMID: 32231342 Free PMC article.
ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth.
Remsberg JR, Suciu RM, Zambetti NA, Hanigan TW, Firestone AJ, Inguva A, Long A, Ngo N, Lum KM, Henry CL, Richardson SK, Predovic M, Huang B, Dix MM, Howell AR, Niphakis MJ, Shannon K, Cravatt BF. Remsberg JR, et al. Among authors: cravatt bf. Nat Chem Biol. 2021 Aug;17(8):856-864. doi: 10.1038/s41589-021-00785-8. Epub 2021 Apr 29. Nat Chem Biol. 2021. PMID: 33927411 Free PMC article.
Selective inhibitors of JAK1 targeting an isoform-restricted allosteric cysteine.
Kavanagh ME, Horning BD, Khattri R, Roy N, Lu JP, Whitby LR, Ye E, Brannon JC, Parker A, Chick JM, Eissler CL, Wong AJ, Rodriguez JL, Rodiles S, Masuda K, Teijaro JR, Simon GM, Patricelli MP, Cravatt BF. Kavanagh ME, et al. Among authors: cravatt bf. Nat Chem Biol. 2022 Dec;18(12):1388-1398. doi: 10.1038/s41589-022-01098-0. Epub 2022 Sep 12. Nat Chem Biol. 2022. PMID: 36097295 Free PMC article.
Author Correction: Selective inhibitors of JAK1 targeting an isoform-restricted allosteric cysteine.
Kavanagh ME, Horning BD, Khattri R, Roy N, Lu JP, Whitby LR, Ye E, Brannon JC, Parker A, Chick JM, Eissler CL, Wong AJ, Rodriguez JL, Rodiles S, Masuda K, Teijaro JR, Simon GM, Patricelli MP, Cravatt BF. Kavanagh ME, et al. Among authors: cravatt bf. Nat Chem Biol. 2022 Nov;18(11):1288. doi: 10.1038/s41589-022-01181-6. Nat Chem Biol. 2022. PMID: 36180594 No abstract available.
580 results