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SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.
Lukinović V, Hausmann S, Roth GS, Oyeniran C, Ahmad T, Tsao N, Brickner JR, Casanova AG, Chuffart F, Benitez AM, Vayr J, Rodell R, Tardif M, Jansen PWTC, Couté Y, Vermeulen M, Hainaut P, Mazur PK, Mosammaparast N, Reynoird N. Lukinović V, et al. Among authors: tsao n. Cancer Discov. 2022 Sep 2;12(9):2158-2179. doi: 10.1158/2159-8290.CD-21-0205. Cancer Discov. 2022. PMID: 35819319 Free PMC article.
Aberrant RNA methylation triggers recruitment of an alkylation repair complex.
Tsao N, Brickner JR, Rodell R, Ganguly A, Wood M, Oyeniran C, Ahmad T, Sun H, Bacolla A, Zhang L, Lukinović V, Soll JM, Townley BA, Casanova AG, Tainer JA, He C, Vindigni A, Reynoird N, Mosammaparast N. Tsao N, et al. Mol Cell. 2021 Oct 21;81(20):4228-4242.e8. doi: 10.1016/j.molcel.2021.09.024. Mol Cell. 2021. PMID: 34686315 Free PMC article.
A functional link between lariat debranching enzyme and the intron-binding complex is defective in non-photosensitive trichothiodystrophy.
Townley BA, Buerer L, Tsao N, Bacolla A, Mansoori F, Rusanov T, Clark N, Goodarzi N, Schmidt N, Srivatsan SN, Sun H, Sample RA, Brickner JR, McDonald D, Tsai MS, Walter MJ, Wozniak DF, Holehouse AS, Pena V, Tainer JA, Fairbrother WG, Mosammaparast N. Townley BA, et al. Among authors: tsao n. Mol Cell. 2023 Jul 6;83(13):2258-2275.e11. doi: 10.1016/j.molcel.2023.06.011. Epub 2023 Jun 26. Mol Cell. 2023. PMID: 37369199
How RNA impacts DNA repair.
Tsao N, Ashour ME, Mosammaparast N. Tsao N, et al. DNA Repair (Amst). 2023 Nov;131:103564. doi: 10.1016/j.dnarep.2023.103564. Epub 2023 Sep 9. DNA Repair (Amst). 2023. PMID: 37776841 Review.
Thymidylate kinase is critical for DNA repair via ATM-dependent Tip60 complex formation.
Hu CM, Tsao N, Wang YT, Chen YJ, Chang ZF. Hu CM, et al. Among authors: tsao n. FASEB J. 2019 Feb;33(2):2017-2025. doi: 10.1096/fj.201800856R. Epub 2018 Sep 10. FASEB J. 2019. PMID: 30199284
Together, these findings suggest that Tip60-ATM signaling has a functional contribution to the recruitment of TMPK to DNA damage sites, thereby increasing local dTTP synthesis for DNA repair.-Hu, C.-M., Tsao, N., Wang, Y.-T., Chen, Y.-J., Chang, Z.-F. Thymidylate ki …
Together, these findings suggest that Tip60-ATM signaling has a functional contribution to the recruitment of TMPK to DNA damage sites, ther …
175 results