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Targeting Oncogenic RAS Protein.
Longo DL, Rosen N. Longo DL, et al. Among authors: rosen n. N Engl J Med. 2022 Jul 14;387(2):184-186. doi: 10.1056/NEJMe2206831. N Engl J Med. 2022. PMID: 35830646 No abstract available.
ras Mutation: does it have clinical import?
Rosen N, Sepp-Lorenzino L. Rosen N, et al. Cancer J Sci Am. 1997 Sep-Oct;3(5):271-2. Cancer J Sci Am. 1997. PMID: 9327149 Review. No abstract available.
Resistance to BRAF inhibition in melanomas.
Solit DB, Rosen N. Solit DB, et al. Among authors: rosen n. N Engl J Med. 2011 Feb 24;364(8):772-4. doi: 10.1056/NEJMcibr1013704. N Engl J Med. 2011. PMID: 21345109 No abstract available.
Progression of RAS-mutant leukemia during RAF inhibitor treatment.
Callahan MK, Rampal R, Harding JJ, Klimek VM, Chung YR, Merghoub T, Wolchok JD, Solit DB, Rosen N, Abdel-Wahab O, Levine RL, Chapman PB. Callahan MK, et al. Among authors: rosen n. N Engl J Med. 2012 Dec 13;367(24):2316-21. doi: 10.1056/NEJMoa1208958. Epub 2012 Nov 7. N Engl J Med. 2012. PMID: 23134356 Free PMC article.
Tumours with class 3 BRAF mutants are sensitive to the inhibition of activated RAS.
Yao Z, Yaeger R, Rodrik-Outmezguine VS, Tao A, Torres NM, Chang MT, Drosten M, Zhao H, Cecchi F, Hembrough T, Michels J, Baumert H, Miles L, Campbell NM, de Stanchina E, Solit DB, Barbacid M, Taylor BS, Rosen N. Yao Z, et al. Among authors: rosen n. Nature. 2017 Aug 10;548(7666):234-238. doi: 10.1038/nature23291. Epub 2017 Aug 2. Nature. 2017. PMID: 28783719 Free PMC article.
RAF dimer inhibition enhances the antitumor activity of MEK inhibitors in K-RAS mutant tumors.
Yuan X, Tang Z, Du R, Yao Z, Cheung SH, Zhang X, Wei J, Zhao Y, Du Y, Liu Y, Hu X, Gong W, Liu Y, Gao Y, Huang Z, Cao Z, Wei M, Zhou C, Wang L, Rosen N, Smith PD, Luo L. Yuan X, et al. Among authors: rosen n. Mol Oncol. 2020 Aug;14(8):1833-1849. doi: 10.1002/1878-0261.12698. Epub 2020 May 18. Mol Oncol. 2020. PMID: 32336014 Free PMC article.
Finally, Effective Inhibitors of Mutant KRAS.
Rosen N. Rosen N. N Engl J Med. 2021 Jun 24;384(25):2447-2449. doi: 10.1056/NEJMe2107884. N Engl J Med. 2021. PMID: 34161711 No abstract available.
724 results