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Aging alters antiviral signaling pathways resulting in functional impairment in innate immunity in response to pattern recognition receptor agonists.
Connors J, Taramangalam B, Cusimano G, Bell MR, Matt SM, Runner K, Gaskill PJ, DeFilippis V, Nikolich-Žugich J, Kutzler MA, Haddad EK. Connors J, et al. Among authors: bell mr. Geroscience. 2022 Oct;44(5):2555-2572. doi: 10.1007/s11357-022-00612-5. Epub 2022 Jul 18. Geroscience. 2022. PMID: 35849213 Free PMC article.
The impact of immuno-aging on SARS-CoV-2 vaccine development.
Connors J, Bell MR, Marcy J, Kutzler M, Haddad EK. Connors J, et al. Among authors: bell mr. Geroscience. 2021 Feb;43(1):31-51. doi: 10.1007/s11357-021-00323-3. Epub 2021 Feb 11. Geroscience. 2021. PMID: 33569701 Free PMC article. Review.
Improved Durability to SARS-CoV-2 Vaccine Immunity following Coimmunization with Molecular Adjuvant Adenosine Deaminase-1.
Cusimano GM, Gary EN, Bell MR, Warner BM, Connors J, Tursi NJ, Ali AR, Zhang S, Canziani G, Taramangalam B, Gordon EA, Chaiken IM, Wootton SK, Smith T, Ramos S, Kobasa D, Weiner DB, Kutzler MA, Haddad EK. Cusimano GM, et al. Among authors: bell mr. J Immunol. 2022 Jul 1;209(1):118-127. doi: 10.4049/jimmunol.2200056. Epub 2022 Jun 24. J Immunol. 2022. PMID: 35750334 Free PMC article.
Adenosine deaminase augments SARS-CoV-2 specific cellular and humoral responses in aged mouse models of immunization and challenge.
Gary EN, Tursi NJ, Warner BM, Cuismano G, Connors J, Parzych EM, Griffin BD, Bell MR, Ali AR, Frase D, Hojecki CE, Canziani GA, Chaiken I, Kannan T, Moffat E, Embury-Hyatt C, Wooton SK, Kossenkov A, Patel A, Kobasa D, Kutzler MA, Haddad EK, Weiner DB. Gary EN, et al. Among authors: bell mr. Front Immunol. 2023 Mar 14;14:1138609. doi: 10.3389/fimmu.2023.1138609. eCollection 2023. Front Immunol. 2023. PMID: 36999023 Free PMC article.
Multi-omic longitudinal study reveals immune correlates of clinical course among hospitalized COVID-19 patients.
Diray-Arce J, Fourati S, Doni Jayavelu N, Patel R, Maguire C, Chang AC, Dandekar R, Qi J, Lee BH, van Zalm P, Schroeder A, Chen E, Konstorum A, Brito A, Gygi JP, Kho A, Chen J, Pawar S, Gonzalez-Reiche AS, Hoch A, Milliren CE, Overton JA, Westendorf K; IMPACC Network; Cairns CB, Rouphael N, Bosinger SE, Kim-Schulze S, Krammer F, Rosen L, Grubaugh ND, van Bakel H, Wilson M, Rajan J, Steen H, Eckalbar W, Cotsapas C, Langelier CR, Levy O, Altman MC, Maecker H, Montgomery RR, Haddad EK, Sekaly RP, Esserman D, Ozonoff A, Becker PM, Augustine AD, Guan L, Peters B, Kleinstein SH. Diray-Arce J, et al. Cell Rep Med. 2023 Jun 20;4(6):101079. doi: 10.1016/j.xcrm.2023.101079. Epub 2023 May 23. Cell Rep Med. 2023. PMID: 37327781 Free PMC article.
The molecular immune modulator adenosine deaminase-1 enhances HIV specific humoral and cellular responses to a native-like HIV envelope trimer DNA vaccine.
Kutzler MA, Cusimano G, Joyner D, Konopka E, Muir R, Barnette P, Guderian M, Del Moral-Sánchez I, Derking R, Bijl T, Snitselaar J, Rotsides P, Woloszczuk K, Bell M, Canziani G, Chaiken I, Hessell A, Bartsch Y, Sanders R, Haddad E. Kutzler MA, et al. Res Sq [Preprint]. 2024 Apr 22:rs.3.rs-4139764. doi: 10.21203/rs.3.rs-4139764/v1. Res Sq. 2024. PMID: 38746176 Free PMC article. Preprint.
321 results