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Aging alters antiviral signaling pathways resulting in functional impairment in innate immunity in response to pattern recognition receptor agonists.
Connors J, Taramangalam B, Cusimano G, Bell MR, Matt SM, Runner K, Gaskill PJ, DeFilippis V, Nikolich-Žugich J, Kutzler MA, Haddad EK. Connors J, et al. Among authors: haddad ek. Geroscience. 2022 Oct;44(5):2555-2572. doi: 10.1007/s11357-022-00612-5. Epub 2022 Jul 18. Geroscience. 2022. PMID: 35849213 Free PMC article.
Global analyses revealed age-related alterations in innate immune responses after stimulation of pathogen recognition receptors.
Metcalf TU, Cubas RA, Ghneim K, Cartwright MJ, Grevenynghe JV, Richner JM, Olagnier DP, Wilkinson PA, Cameron MJ, Park BS, Hiscott JB, Diamond MS, Wertheimer AM, Nikolich-Zugich J, Haddad EK. Metcalf TU, et al. Among authors: haddad ek. Aging Cell. 2015 Jun;14(3):421-32. doi: 10.1111/acel.12320. Epub 2015 Feb 27. Aging Cell. 2015. PMID: 25728020 Free PMC article.
CCR10 expression is required for the adjuvant activity of the mucosal chemokine CCL28 when delivered in the context of an HIV-1 Env DNA vaccine.
Gary EN, Kathuria N, Makurumidze G, Curatola A, Ramamurthi A, Bernui ME, Myles D, Yan J, Pankhong P, Muthumani K, Haddad E, Humeau L, Weiner DB, Kutzler MA. Gary EN, et al. Vaccine. 2020 Mar 4;38(11):2626-2635. doi: 10.1016/j.vaccine.2020.01.023. Epub 2020 Feb 10. Vaccine. 2020. PMID: 32057572 Free PMC article.
124 results