Osawa Y - Search Results

1

Inhibition of CBP/β-catenin signaling ameliorated fibrosis in cholestatic liver disease.

Kimura M, Nishikawa K, Osawa Y, Imamura J, Yamaji K, Harada K, Yatsuhashi H, Murata K, Miura K, Tanaka A, Kanto T, Kohara M, Kamisawa T, Kimura K. Kimura M, et al. Among authors: osawa y. Hepatol Commun. 2022 Oct;6(10):2732-2747. doi: 10.1002/hep4.2043. Epub 2022 Jul 20. Hepatol Commun. 2022. PMID: 35855613 Free PMC article.

2

Leflunomide protects from T-cell-mediated liver injury in mice through inhibition of nuclear factor kappaB.

Imose M, Nagaki M, Kimura K, Takai S, Imao M, Naiki T, Osawa Y, Asano T, Hayashi H, Moriwaki H. Imose M, et al. Among authors: osawa y. Hepatology. 2004 Nov;40(5):1160-9. doi: 10.1002/hep.20438. Hepatology. 2004. PMID: 15455409

3

Epimorphin, a morphogenic protein, induces proteases in rodent hepatocytes through NF-kappaB.

Miura K, Yoshino R, Hirai Y, Goto T, Ohshima S, Mikami K, Yoneyama K, Watanabe D, Sato M, Senoo H, Kodama Y, Osawa Y, Brenner DA, Watanabe S. Miura K, et al. Among authors: osawa y. J Hepatol. 2007 Dec;47(6):834-43. doi: 10.1016/j.jhep.2007.07.024. Epub 2007 Sep 25. J Hepatol. 2007. PMID: 17935821

4

Role of acid sphingomyelinase of Kupffer cells in cholestatic liver injury in mice.

Osawa Y, Seki E, Adachi M, Suetsugu A, Ito H, Moriwaki H, Seishima M, Nagaki M. Osawa Y, et al. Hepatology. 2010 Jan;51(1):237-45. doi: 10.1002/hep.23262. Hepatology. 2010. PMID: 19821528

5

Immunological analysis of a patient with hepatitis B virus (HBV) reactivation after bone marrow transplantation.

Kowazaki Y, Osawa Y, Imamura J, Ohashi K, Sakamaki H, Kimura K. Kowazaki Y, et al. Among authors: osawa y. Intern Med. 2015;54(10):1213-7. doi: 10.2169/internalmedicine.54.3706. Epub 2015 May 15. Intern Med. 2015. PMID: 25986258 Free article.

6

Inhibition of Cyclic Adenosine Monophosphate (cAMP)-response Element-binding Protein (CREB)-binding Protein (CBP)/β-Catenin Reduces Liver Fibrosis in Mice.

Osawa Y, Oboki K, Imamura J, Kojika E, Hayashi Y, Hishima T, Saibara T, Shibasaki F, Kohara M, Kimura K. Osawa Y, et al. EBioMedicine. 2015 Oct 8;2(11):1751-8. doi: 10.1016/j.ebiom.2015.10.010. eCollection 2015 Nov. EBioMedicine. 2015. PMID: 26870800 Free PMC article.

7

Selective inhibitor of Wnt/β-catenin/CBP signaling ameliorates hepatitis C virus-induced liver fibrosis in mouse model.

Tokunaga Y, Osawa Y, Ohtsuki T, Hayashi Y, Yamaji K, Yamane D, Hara M, Munekata K, Tsukiyama-Kohara K, Hishima T, Kojima S, Kimura K, Kohara M. Tokunaga Y, et al. Among authors: osawa y. Sci Rep. 2017 Mar 23;7(1):325. doi: 10.1038/s41598-017-00282-w. Sci Rep. 2017. PMID: 28336942 Free PMC article.

8

Pro-angiogenic TIE-2-expressing monocytes/TEMs as a biomarker of the effect of sorafenib in patients with advanced hepatocellular carcinoma.

Shoji H, Yoshio S, Mano Y, Doi H, Sugiyama M, Osawa Y, Kimura K, Arai T, Itokawa N, Atsukawa M, Aoki Y, Fukai M, Taketomi A, Mizokami M, Kanto T. Shoji H, et al. Among authors: osawa y. Int J Cancer. 2017 Sep 1;141(5):1011-1017. doi: 10.1002/ijc.30804. Epub 2017 Jun 8. Int J Cancer. 2017. PMID: 28555943 Free article. Clinical Trial.

9

Safety, Tolerability, and Preliminary Efficacy of the Anti-Fibrotic Small Molecule PRI-724, a CBP/β-Catenin Inhibitor, in Patients with Hepatitis C Virus-related Cirrhosis: A Single-Center, Open-Label, Dose Escalation Phase 1 Trial.

Kimura K, Ikoma A, Shibakawa M, Shimoda S, Harada K, Saio M, Imamura J, Osawa Y, Kimura M, Nishikawa K, Okusaka T, Morita S, Inoue K, Kanto T, Todaka K, Nakanishi Y, Kohara M, Mizokami M. Kimura K, et al. Among authors: osawa y. EBioMedicine. 2017 Sep;23:79-87. doi: 10.1016/j.ebiom.2017.08.016. Epub 2017 Aug 19. EBioMedicine. 2017. PMID: 28844410 Free PMC article. Clinical Trial.

10

Tumor necrosis factor-α-mediated hepatocyte apoptosis stimulates fibrosis in the steatotic liver in mice.

Osawa Y, Kojika E, Hayashi Y, Kimura M, Nishikawa K, Yoshio S, Doi H, Kanto T, Kimura K. Osawa Y, et al. Hepatol Commun. 2018 Feb 13;2(4):407-420. doi: 10.1002/hep4.1158. eCollection 2018 Apr. Hepatol Commun. 2018. PMID: 29619419 Free PMC article.

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