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Self-Masked Aldehyde Inhibitors of Human Cathepsin L Are Potent Anti-CoV-2 Agents.
Front Chem. 2022 Jul 4;10:867928. doi: 10.3389/fchem.2022.867928. eCollection 2022.
Front Chem. 2022.
PMID: 35860632
Free PMC article.
Self-Masked Aldehyde Inhibitors: A Novel Strategy for Inhibiting Cysteine Proteases.
Li L, Chenna BC, Yang KS, Cole TR, Goodall ZT, Giardini M, Moghadamchargari Z, Hernandez EA, Gomez J, Calvet CM, Bernatchez JA, Mellott DM, Zhu J, Rademacher A, Thomas D, Blankenship LR, Drelich A, Laganowsky A, Tseng CK, Liu WR, Wand AJ, Cruz-Reyes J, Siqueira-Neto JL, Meek TD.
Li L, et al. Among authors: chenna bc.
J Med Chem. 2021 Aug 12;64(15):11267-11287. doi: 10.1021/acs.jmedchem.1c00628. Epub 2021 Jul 21.
J Med Chem. 2021.
PMID: 34288674
Free PMC article.
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Peptidomimetic Vinyl Heterocyclic Inhibitors of Cruzain Effect Antitrypanosomal Activity.
Chenna BC, Li L, Mellott DM, Zhai X, Siqueira-Neto JL, Calvet Alvarez C, Bernatchez JA, Desormeaux E, Alvarez Hernandez E, Gomez J, McKerrow JH, Cruz-Reyes J, Meek TD.
Chenna BC, et al.
J Med Chem. 2020 Mar 26;63(6):3298-3316. doi: 10.1021/acs.jmedchem.9b02078. Epub 2020 Mar 17.
J Med Chem. 2020.
PMID: 32125159
Free PMC article.
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A Clinical-Stage Cysteine Protease Inhibitor blocks SARS-CoV-2 Infection of Human and Monkey Cells.
Mellott DM, Tseng CT, Drelich A, Fajtová P, Chenna BC, Kostomiris DH, Hsu J, Zhu J, Taylor ZW, Kocurek KI, Tat V, Katzfuss A, Li L, Giardini MA, Skinner D, Hirata K, Yoon MC, Beck S, Carlin AF, Clark AE, Beretta L, Maneval D, Hook V, Frueh F, Hurst BL, Wang H, Raushel FM, O'Donoghue AJ, de Siqueira-Neto JL, Meek TD, McKerrow JH.
Mellott DM, et al. Among authors: chenna bc.
ACS Chem Biol. 2021 Apr 16;16(4):642-650. doi: 10.1021/acschembio.0c00875. Epub 2021 Mar 31.
ACS Chem Biol. 2021.
PMID: 33787221
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A cysteine protease inhibitor blocks SARS-CoV-2 infection of human and monkey cells.
Mellott DM, Tseng CT, Drelich A, Fajtová P, Chenna BC, Kostomiris DH, Hsu J, Zhu J, Taylor ZW, Tat V, Katzfuss A, Li L, Giardini MA, Skinner D, Hirata K, Beck S, Carlin AF, Clark AE, Beretta L, Maneval D, Frueh F, Hurst BL, Wang H, Kocurek KI, Raushel FM, O'Donoghue AJ, de Siqueira-Neto JL, Meek TD, McKerrow JH.
Mellott DM, et al. Among authors: chenna bc.
bioRxiv [Preprint]. 2020 Oct 30:2020.10.23.347534. doi: 10.1101/2020.10.23.347534.
bioRxiv. 2020.
PMID: 33140046
Free PMC article.
Updated.
Preprint.
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Synthesis and characterization of potent inhibitors of Trypanosoma cruzi dihydrofolate reductase.
Schormann N, Velu SE, Murugesan S, Senkovich O, Walker K, Chenna BC, Shinkre B, Desai A, Chattopadhyay D.
Schormann N, et al. Among authors: chenna bc.
Bioorg Med Chem. 2010 Jun 1;18(11):4056-66. doi: 10.1016/j.bmc.2010.04.020. Epub 2010 Apr 9.
Bioorg Med Chem. 2010.
PMID: 20452776
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Synthesis and structure activity relationship studies of novel Staphylococcus aureus Sortase A inhibitors.
Chenna BC, King JR, Shinkre BA, Glover AL, Lucius AL, Velu SE.
Chenna BC, et al.
Eur J Med Chem. 2010 Sep;45(9):3752-61. doi: 10.1016/j.ejmech.2010.05.024. Epub 2010 May 20.
Eur J Med Chem. 2010.
PMID: 20541848
Free PMC article.
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Identification of novel inhibitors of bacterial surface enzyme Staphylococcus aureus Sortase A.
Chenna BC, Shinkre BA, King JR, Lucius AL, Narayana SV, Velu SE.
Chenna BC, et al.
Bioorg Med Chem Lett. 2008 Jan 1;18(1):380-5. doi: 10.1016/j.bmcl.2007.10.051. Epub 2007 Oct 18.
Bioorg Med Chem Lett. 2008.
PMID: 18023345
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