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Intervention with methotrexate in patients with arthralgia at risk of rheumatoid arthritis to reduce the development of persistent arthritis and its disease burden (TREAT EARLIER): a randomised, double-blind, placebo-controlled, proof-of-concept trial.
Krijbolder DI, Verstappen M, van Dijk BT, Dakkak YJ, Burgers LE, Boer AC, Park YJ, de Witt-Luth ME, Visser K, Kok MR, Molenaar ETH, de Jong PHP, Böhringer S, Huizinga TWJ, Allaart CF, Niemantsverdriet E, van der Helm-van Mil AHM. Krijbolder DI, et al. Among authors: molenaar eth. Lancet. 2022 Jul 23;400(10348):283-294. doi: 10.1016/S0140-6736(22)01193-X. Lancet. 2022. PMID: 35871815 Clinical Trial.
Remission induction therapy with methotrexate and prednisone in patients with early rheumatoid and undifferentiated arthritis (the IMPROVED study).
Wevers-de Boer K, Visser K, Heimans L, Ronday HK, Molenaar E, Groenendael JH, Peeters AJ, Westedt ML, Collée G, de Sonnaville PB, Grillet BA, Huizinga TW, Allaart CF. Wevers-de Boer K, et al. Ann Rheum Dis. 2012 Sep;71(9):1472-7. doi: 10.1136/annrheumdis-2011-200736. Epub 2012 Mar 8. Ann Rheum Dis. 2012. PMID: 22402145 Clinical Trial.
Determinants of reaching drug-free remission in patients with early rheumatoid or undifferentiated arthritis after one year of remission-steered treatment.
Wevers-de Boer KV, Heimans L, Visser K, Schouffoer AA, Molenaar ET, van Groenendael JH, Peeters AJ, Speyer I, Collée G, Huizinga TW, Allaart CF. Wevers-de Boer KV, et al. Rheumatology (Oxford). 2015 Aug;54(8):1380-4. doi: 10.1093/rheumatology/keu477. Epub 2015 Feb 15. Rheumatology (Oxford). 2015. PMID: 25687553
Two-year results of disease activity score (DAS)-remission-steered treatment strategies aiming at drug-free remission in early arthritis patients (the IMPROVED-study).
Heimans L, Akdemir G, Boer KV, Goekoop-Ruiterman YP, Molenaar ET, van Groenendael JH, Peeters AJ, Steup-Beekman GM, Lard LR, de Sonnaville PB, Grillet BA, Huizinga TW, Allaart CF. Heimans L, et al. Arthritis Res Ther. 2016 Jan 21;18:23. doi: 10.1186/s13075-015-0912-y. Arthritis Res Ther. 2016. PMID: 26794605 Free PMC article. Clinical Trial.
Low dose, add-on prednisolone in patients with rheumatoid arthritis aged 65+: the pragmatic randomised, double-blind placebo-controlled GLORIA trial.
Boers M, Hartman L, Opris-Belinski D, Bos R, Kok MR, Da Silva JA, Griep EN, Klaasen R, Allaart CF, Baudoin P, Raterman HG, Szekanecz Z, Buttgereit F, Masaryk P, Klausch LT, Paolino S, Schilder AM, Lems WF, Cutolo M; GLORIA Trial consortium. Boers M, et al. Ann Rheum Dis. 2022 Jul;81(7):925-936. doi: 10.1136/annrheumdis-2021-221957. Epub 2022 May 31. Ann Rheum Dis. 2022. PMID: 35641125 Free PMC article. Clinical Trial.
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