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Partial RAG deficiency in humans induces dysregulated peripheral lymphocyte development and humoral tolerance defect with accumulation of T-bet+ B cells.
Csomos K, Ujhazi B, Blazso P, Herrera JL, Tipton CM, Kawai T, Gordon S, Ellison M, Wu K, Stowell M, Haynes L, Cruz R, Zakota B, Nguyen J, Altrich M, Geier CB, Sharapova S, Dasso JF, Leiding JW, Smith G, Al-Herz W, de Barros Dorna M, Fadugba O, Fronkova E, Kanderova V, Svaton M, Henrickson SE, Hernandez JD, Kuijpers T, Kandilarova SM, Naumova E, Milota T, Sediva A, Moshous D, Neven B, Saco T, Sargur R, Savic S, Sleasman J, Sunkersett G, Ward BR, Komatsu M, Pittaluga S, Kumanovics A, Butte MJ, Cancro MP, Pillai S, Meffre E, Notarangelo LD, Walter JE. Csomos K, et al. Among authors: tipton cm. Nat Immunol. 2022 Aug;23(8):1256-1272. doi: 10.1038/s41590-022-01271-6. Epub 2022 Jul 28. Nat Immunol. 2022. PMID: 35902638 Free PMC article.
Extrafollicular B cell responses correlate with neutralizing antibodies and morbidity in COVID-19.
Woodruff MC, Ramonell RP, Nguyen DC, Cashman KS, Saini AS, Haddad NS, Ley AM, Kyu S, Howell JC, Ozturk T, Lee S, Suryadevara N, Case JB, Bugrovsky R, Chen W, Estrada J, Morrison-Porter A, Derrico A, Anam FA, Sharma M, Wu HM, Le SN, Jenks SA, Tipton CM, Staitieh B, Daiss JL, Ghosn E, Diamond MS, Carnahan RH, Crowe JE Jr, Hu WT, Lee FE, Sanz I. Woodruff MC, et al. Among authors: tipton cm. Nat Immunol. 2020 Dec;21(12):1506-1516. doi: 10.1038/s41590-020-00814-z. Epub 2020 Oct 7. Nat Immunol. 2020. PMID: 33028979 Free PMC article.
Dysregulated naive B cells and de novo autoreactivity in severe COVID-19.
Woodruff MC, Ramonell RP, Haddad NS, Anam FA, Rudolph ME, Walker TA, Truong AD, Dixit AN, Han JE, Cabrera-Mora M, Runnstrom MC, Bugrovsky R, Hom J, Connolly EC, Albizua I, Javia V, Cashman KS, Nguyen DC, Kyu S, Singh Saini A, Piazza M, Tipton CM, Khosroshahi A, Gibson G, Martin GS, Maier CL, Esper A, Jenks SA, Lee FE, Sanz I. Woodruff MC, et al. Among authors: tipton cm. Nature. 2022 Nov;611(7934):139-147. doi: 10.1038/s41586-022-05273-0. Epub 2022 Aug 31. Nature. 2022. PMID: 36044993 Free PMC article.
Distinct transcriptomes and autocrine cytokines underpin maturation and survival of antibody-secreting cells in systemic lupus erythematosus.
Chen W, Hong SH, Jenks SA, Anam FA, Tipton CM, Woodruff MC, Hom JR, Cashman KS, Faliti CE, Wang X, Kyu S, Wei C, Scharer CD, Mi T, Hicks S, Hartson L, Nguyen DC, Khosroshahi A, Lee S, Wang Y, Bugrovsky R, Ishii Y, Lee FE, Sanz I. Chen W, et al. Among authors: tipton cm. Nat Commun. 2024 Mar 1;15(1):1899. doi: 10.1038/s41467-024-46053-w. Nat Commun. 2024. PMID: 38429276 Free PMC article.
The Regulation of Inherently Autoreactive VH4-34-Expressing B Cells in Individuals Living in a Malaria-Endemic Area of West Africa.
Hart GT, Akkaya M, Chida AS, Wei C, Jenks SA, Tipton C, He C, Wendel BS, Skinner J, Arora G, Kayentao K, Ongoiba A, Doumbo O, Traore B, Narum DL, Jiang N, Crompton PD, Sanz I, Pierce SK. Hart GT, et al. J Immunol. 2016 Nov 15;197(10):3841-3849. doi: 10.4049/jimmunol.1600491. Epub 2016 Oct 19. J Immunol. 2016. PMID: 27798155 Free PMC article.
Extrafollicular IgD+ B cells generate IgE antibody secreting cells in the nasal mucosa.
Corrado A, Ramonell RP, Woodruff MC, Tipton C, Wise S, Levy J, DelGaudio J, Kuruvilla ME, Magliocca KR, Tomar D, Garimalla S, Scharer CD, Boss JM, Wu H, Gumber S, Fucile C, Gibson G, Rosenberg A, Sanz I, Lee FE. Corrado A, et al. Mucosal Immunol. 2021 Sep;14(5):1144-1159. doi: 10.1038/s41385-021-00410-w. Epub 2021 May 28. Mucosal Immunol. 2021. PMID: 34050324 Free PMC article.
191 results