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The androgen receptor depends on ligand-binding domain dimerization for transcriptional activation.
El Kharraz S, Dubois V, van Royen ME, Houtsmuller AB, Pavlova E, Atanassova N, Nguyen T, Voet A, Eerlings R, Handle F, Prekovic S, Smeets E, Moris L, Devlies W, Ohlsson C, Poutanen M, Verstrepen KJ, Carmeliet G, Launonen KM, Helminen L, Palvimo JJ, Libert C, Vanderschueren D, Helsen C, Claessens F. El Kharraz S, et al. EMBO Rep. 2021 Dec 6;22(12):e52764. doi: 10.15252/embr.202152764. Epub 2021 Oct 18. EMBO Rep. 2021. PMID: 34661369 Free PMC article.
Antizyme Inhibitor 1 Regulates Matrikine Expression and Enhances the Metastatic Potential of Aggressive Primary Prostate Cancer.
Van den Broeck T, Moris L, Gevaert T, Davicioni E, Boeckx B, Lambrechts D, Helsen C, Handle F, Ghesquière B, Soenen S, Smeets E, Eerlings R, El Kharraz S, Devlies W, Karnes RJ, Lotan T, Van Poppel H, Joniau S, Claessens F. Van den Broeck T, et al. Among authors: el kharraz s. Mol Cancer Res. 2022 Apr 1;20(4):527-541. doi: 10.1158/1541-7786.MCR-21-0388. Mol Cancer Res. 2022. PMID: 35082164
A disease-associated missense mutation in CYP4F3 affects the metabolism of leukotriene B4 via disruption of electron transfer.
Smeets E, Huang S, Lee XY, Van Nieuwenhove E, Helsen C, Handle F, Moris L, El Kharraz S, Eerlings R, Devlies W, Willemsen M, Bücken L, Prezzemolo T, Humblet-Baron S, Voet A, Rochtus A, Van Schepdael A, de Zegher F, Claessens F. Smeets E, et al. Among authors: el kharraz s. J Cachexia Sarcopenia Muscle. 2022 Aug;13(4):2242-2253. doi: 10.1002/jcsm.13022. Epub 2022 Jun 9. J Cachexia Sarcopenia Muscle. 2022. PMID: 35686338 Free PMC article.
Rational evolution for altering the ligand preference of estrogen receptor alpha.
Eerlings R, Gupta P, Lee XY, Nguyen T, El Kharraz S, Handle F, Smeets E, Moris L, Devlies W, Vandewinkel B, Thiry I, Ta DT, Gorkovskiy A, Voordeckers K, Henckaerts E, Pinheiro VB, Claessens F, Verstrepen KJ, Voet A, Helsen C. Eerlings R, et al. Among authors: el kharraz s. Protein Sci. 2024 Apr;33(4):e4940. doi: 10.1002/pro.4940. Protein Sci. 2024. PMID: 38511482
Testosterone Restores Body Composition, Bone Mass, and Bone Strength Following Early Puberty Suppression in a Mouse Model Mimicking the Clinical Strategy in Trans Boys.
Dubois V, Ciancia S, Doms S, El Kharraz S, Sommers V, Kim NR, David K, Van Dijck J, Valle-Tenney R, Maes C, Antonio L, Decallonne B, Carmeliet G, Claessens F, Cools M, Vanderschueren D. Dubois V, et al. Among authors: el kharraz s. J Bone Miner Res. 2023 Oct;38(10):1497-1508. doi: 10.1002/jbmr.4832. Epub 2023 Jun 8. J Bone Miner Res. 2023. PMID: 37222072 Free article.