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TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.
Dendoncker K, Timmermans S, Vandewalle J, Eggermont M, Lempiäinen J, Paakinaho V, Van Hamme E, Dewaele S, Vandevyver S, Ballegeer M, Souffriau J, Van Wyngene L, Van Looveren K, Vanderhaeghen T, Beyaert R, De Bosscher K, Palvimo JJ, Van Montagu M, Libert C. Dendoncker K, et al. Among authors: libert c. Proc Natl Acad Sci U S A. 2019 Jun 25;116(26):12942-12951. doi: 10.1073/pnas.1821565116. Epub 2019 Jun 10. Proc Natl Acad Sci U S A. 2019. PMID: 31182584 Free PMC article.
Combined glucocorticoid resistance and hyperlactatemia contributes to lethal shock in sepsis.
Vandewalle J, Timmermans S, Paakinaho V, Vancraeynest L, Dewyse L, Vanderhaeghen T, Wallaeys C, Van Wyngene L, Van Looveren K, Nuyttens L, Eggermont M, Dewaele S, Velho TR, Moita LF, Weis S, Sponholz C, van Grunsven LA, Dewerchin M, Carmeliet P, De Bosscher K, Van de Voorde J, Palvimo JJ, Libert C. Vandewalle J, et al. Among authors: libert c. Cell Metab. 2021 Sep 7;33(9):1763-1776.e5. doi: 10.1016/j.cmet.2021.07.002. Epub 2021 Jul 23. Cell Metab. 2021. PMID: 34302744 Free article.
The androgen receptor depends on ligand-binding domain dimerization for transcriptional activation.
El Kharraz S, Dubois V, van Royen ME, Houtsmuller AB, Pavlova E, Atanassova N, Nguyen T, Voet A, Eerlings R, Handle F, Prekovic S, Smeets E, Moris L, Devlies W, Ohlsson C, Poutanen M, Verstrepen KJ, Carmeliet G, Launonen KM, Helminen L, Palvimo JJ, Libert C, Vanderschueren D, Helsen C, Claessens F. El Kharraz S, et al. Among authors: libert c. EMBO Rep. 2021 Dec 6;22(12):e52764. doi: 10.15252/embr.202152764. Epub 2021 Oct 18. EMBO Rep. 2021. PMID: 34661369 Free PMC article.
Reprogramming of glucocorticoid receptor function by hypoxia.
Vanderhaeghen T, Timmermans S, Watts D, Paakinaho V, Eggermont M, Vandewalle J, Wallaeys C, Van Wyngene L, Van Looveren K, Nuyttens L, Dewaele S, Vanden Berghe J, Lemeire K, De Backer J, Dirkx L, Vanden Berghe W, Caljon G, Ghesquière B, De Bosscher K, Wielockx B, Palvimo JJ, Beyaert R, Libert C. Vanderhaeghen T, et al. Among authors: libert c. EMBO Rep. 2022 Jan 5;23(1):e53083. doi: 10.15252/embr.202153083. Epub 2021 Oct 26. EMBO Rep. 2022. PMID: 34699114 Free PMC article.
Point mutation I634A in the glucocorticoid receptor causes embryonic lethality by reduced ligand binding.
Timmermans S, Verhoog NJD, Van Looveren K, Dewaele S, Hochepied T, Eggermont M, Gilbert B, Boerema-de Munck A, Vanderhaeghen T, Vanden Berghe J, Garcia Gonzalez N, Vandewalle J, Bloch Y, Provost M, Savvides SN, De Bosscher K, Declercq W, Rottier RJ, Louw A, Libert C. Timmermans S, et al. Among authors: libert c. J Biol Chem. 2022 Feb;298(2):101574. doi: 10.1016/j.jbc.2022.101574. Epub 2022 Jan 8. J Biol Chem. 2022. PMID: 35007536 Free PMC article.
Sepsis: a failing starvation response.
Vandewalle J, Libert C. Vandewalle J, et al. Among authors: libert c. Trends Endocrinol Metab. 2022 Apr;33(4):292-304. doi: 10.1016/j.tem.2022.01.006. Epub 2022 Feb 15. Trends Endocrinol Metab. 2022. PMID: 35181202 Review.
Novel assays monitoring direct glucocorticoid receptor protein activity exhibit high predictive power for ligand activity on endogenous gene targets.
Van Moortel L, Thommis J, Maertens B, Staes A, Clarisse D, De Sutter D, Libert C, Meijer OC, Eyckerman S, Gevaert K, De Bosscher K. Van Moortel L, et al. Among authors: libert c. Biomed Pharmacother. 2022 Aug;152:113218. doi: 10.1016/j.biopha.2022.113218. Epub 2022 Jun 13. Biomed Pharmacother. 2022. PMID: 35709653 Free article.
310 results