Matthes S - Search Results

1

Structure-Based Design of Xanthine-Benzimidazole Derivatives as Novel and Potent Tryptophan Hydroxylase Inhibitors.

Specker E, Matthes S, Wesolowski R, Schütz A, Grohmann M, Alenina N, Pleimes D, Mallow K, Neuenschwander M, Gogolin A, Weise M, Pfeifer J, Ziebart N, Heinemann U, von Kries JP, Nazaré M, Bader M. Specker E, et al. Among authors: matthes s. J Med Chem. 2022 Aug 25;65(16):11126-11149. doi: 10.1021/acs.jmedchem.2c00598. Epub 2022 Aug 3. J Med Chem. 2022. PMID: 35921615

2

Tryptophan hydroxylase as novel target for the treatment of depressive disorders.

Matthes S, Mosienko V, Bashammakh S, Alenina N, Bader M. Matthes S, et al. Pharmacology. 2010;85(2):95-109. doi: 10.1159/000279322. Epub 2010 Feb 3. Pharmacology. 2010. PMID: 20130443 Free article. Review.

3

Exaggerated aggression and decreased anxiety in mice deficient in brain serotonin.

Mosienko V, Bert B, Beis D, Matthes S, Fink H, Bader M, Alenina N. Mosienko V, et al. Among authors: matthes s. Transl Psychiatry. 2012 May 29;2(5):e122. doi: 10.1038/tp.2012.44. Transl Psychiatry. 2012. PMID: 22832966 Free PMC article.

4

Adaptive changes in serotonin metabolism preserve normal behavior in mice with reduced TPH2 activity.

Mosienko V, Matthes S, Hirth N, Beis D, Flinders M, Bader M, Hansson AC, Alenina N. Mosienko V, et al. Among authors: matthes s. Neuropharmacology. 2014 Oct;85:73-80. doi: 10.1016/j.neuropharm.2014.05.015. Epub 2014 May 24. Neuropharmacology. 2014. PMID: 24863038

5

Life without brain serotonin: reevaluation of serotonin function with mice deficient in brain serotonin synthesis.

Mosienko V, Beis D, Pasqualetti M, Waider J, Matthes S, Qadri F, Bader M, Alenina N. Mosienko V, et al. Among authors: matthes s. Behav Brain Res. 2015 Jan 15;277:78-88. doi: 10.1016/j.bbr.2014.06.005. Epub 2014 Jun 11. Behav Brain Res. 2015. PMID: 24928769 Review.

6

Reply to Lrp5 regulation of bone mass and gut serotonin synthesis.

Cui Y, Niziolek PJ, MacDonald BT, Alenina N, Matthes S, Jacobsen CM, Conlon RA, Brommage R, Powell DR, He X, Bader M, Williams BO, Warman ML, Robling AG. Cui Y, et al. Among authors: matthes s. Nat Med. 2014 Nov;20(11):1229-30. doi: 10.1038/nm.3697. Nat Med. 2014. PMID: 25375917 Free PMC article. No abstract available.

7

Peripheral Serotonin Synthesis as a New Drug Target.

Matthes S, Bader M. Matthes S, et al. Trends Pharmacol Sci. 2018 Jun;39(6):560-572. doi: 10.1016/j.tips.2018.03.004. Epub 2018 Apr 5. Trends Pharmacol Sci. 2018. PMID: 29628275 Review.

8

Depletion of angiotensin-converting enzyme 2 reduces brain serotonin and impairs the running-induced neurogenic response.

Klempin F, Mosienko V, Matthes S, Villela DC, Todiras M, Penninger JM, Bader M, Santos RAS, Alenina N. Klempin F, et al. Among authors: matthes s. Cell Mol Life Sci. 2018 Oct;75(19):3625-3634. doi: 10.1007/s00018-018-2815-y. Epub 2018 Apr 20. Cell Mol Life Sci. 2018. PMID: 29679094 Free PMC article.

9

Targeted Manipulation of Brain Serotonin: RNAi-Mediated Knockdown of Tryptophan Hydroxylase 2 in Rats.

Matthes S, Mosienko V, Popova E, Rivalan M, Bader M, Alenina N. Matthes S, et al. ACS Chem Neurosci. 2019 Jul 17;10(7):3207-3217. doi: 10.1021/acschemneuro.8b00635. Epub 2019 Apr 22. ACS Chem Neurosci. 2019. PMID: 30977636

10

Phenylalanine hydroxylase contributes to serotonin synthesis in mice.

Mordhorst A, Dhandapani P, Matthes S, Mosienko V, Rothe M, Todiras M, Self J, Schunck WH, Schütz A, Bader M, Alenina N. Mordhorst A, et al. Among authors: matthes s. FASEB J. 2021 Jun;35(6):e21648. doi: 10.1096/fj.202100366R. FASEB J. 2021. PMID: 33993565

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