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Page 1
The First Class of Small Molecules Potently Disrupting the YAP-TEAD Interaction by Direct Competition.
ChemMedChem. 2022 Oct 6;17(19):e202200303. doi: 10.1002/cmdc.202200303. Epub 2022 Sep 2.
ChemMedChem. 2022.
PMID: 35950546
Dose and Schedule Determine Distinct Molecular Mechanisms Underlying the Efficacy of the p53-MDM2 Inhibitor HDM201.
Jeay S, Ferretti S, Holzer P, Fuchs J, Chapeau EA, Wartmann M, Sterker D, Romanet V, Murakami M, Kerr G, Durand EY, Gaulis S, Cortes-Cros M, Ruetz S, Stachyra TM, Kallen J, Furet P, Würthner J, Guerreiro N, Halilovic E, Jullion A, Kauffmann A, Kuriakose E, Wiesmann M, Jensen MR, Hofmann F, Sellers WR.
Jeay S, et al. Among authors: chapeau ea.
Cancer Res. 2018 Nov 1;78(21):6257-6267. doi: 10.1158/0008-5472.CAN-18-0338. Epub 2018 Aug 22.
Cancer Res. 2018.
PMID: 30135191
Clinical Trial.
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Optimization of a Class of Dihydrobenzofurane Analogs toward Orally Efficacious YAP-TEAD Protein-Protein Interaction Inhibitors.
Sellner H, Chapeau E, Furet P, Voegtle M, Salem B, Le Douget M, Bordas V, Groell JM, Le Goff AL, Rouzet C, Wietlisbach T, Zimmermann T, McKenna J, Brocklehurst CE, Chène P, Wartmann M, Scheufler C, Kallen J, Williams G, Harlfinger S, Traebert M, Dumotier BM, Schmelzle T, Soldermann N.
Sellner H, et al. Among authors: chapeau e.
ChemMedChem. 2023 Jun 1;18(11):e202300051. doi: 10.1002/cmdc.202300051. Epub 2023 Apr 13.
ChemMedChem. 2023.
PMID: 36988034
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Direct and selective pharmacological disruption of the YAP-TEAD interface by IAG933 inhibits Hippo-dependent and RAS-MAPK-altered cancers.
Chapeau EA, Sansregret L, Galli GG, Chène P, Wartmann M, Mourikis TP, Jaaks P, Baltschukat S, Barbosa IAM, Bauer D, Brachmann SM, Delaunay C, Estadieu C, Faris JE, Furet P, Harlfinger S, Hueber A, Jiménez Núñez E, Kodack DP, Mandon E, Martin T, Mesrouze Y, Romanet V, Scheufler C, Sellner H, Stamm C, Sterker D, Tordella L, Hofmann F, Soldermann N, Schmelzle T.
Chapeau EA, et al.
Nat Cancer. 2024 Apr 2. doi: 10.1038/s43018-024-00754-9. Online ahead of print.
Nat Cancer. 2024.
PMID: 38565920
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Resistance mechanisms to TP53-MDM2 inhibition identified by in vivo piggyBac transposon mutagenesis screen in an Arf-/- mouse model.
Chapeau EA, Gembarska A, Durand EY, Mandon E, Estadieu C, Romanet V, Wiesmann M, Tiedt R, Lehar J, de Weck A, Rad R, Barys L, Jeay S, Ferretti S, Kauffmann A, Sutter E, Grevot A, Moulin P, Murakami M, Sellers WR, Hofmann F, Jensen MR.
Chapeau EA, et al.
Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):3151-3156. doi: 10.1073/pnas.1620262114. Epub 2017 Mar 6.
Proc Natl Acad Sci U S A. 2017.
PMID: 28265066
Free PMC article.
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Deciphering mechanisms of response and resistance in large-scale mouse cancer screens.
Prahallad A, Jensen MR, Chapeau EA.
Prahallad A, et al. Among authors: chapeau ea.
Curr Opin Genet Dev. 2019 Feb;54:48-54. doi: 10.1016/j.gde.2019.02.006. Epub 2019 Apr 4.
Curr Opin Genet Dev. 2019.
PMID: 30954760
Review.
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A conditional inducible JAK2V617F transgenic mouse model reveals myeloproliferative disease that is reversible upon switching off transgene expression.
Chapeau EA, Mandon E, Gill J, Romanet V, Ebel N, Powajbo V, Andraos-Rey R, Qian Z, Kininis M, Zumstein-Mecker S, Ito M, Hynes NE, Tiedt R, Hofmann F, Eshkind L, Bockamp E, Kinzel B, Mueller M, Murakami M, Baffert F, Radimerski T.
Chapeau EA, et al.
PLoS One. 2019 Oct 10;14(10):e0221635. doi: 10.1371/journal.pone.0221635. eCollection 2019.
PLoS One. 2019.
PMID: 31600213
Free PMC article.
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Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism.
Zhang EE, Chapeau E, Hagihara K, Feng GS.
Zhang EE, et al. Among authors: chapeau e.
Proc Natl Acad Sci U S A. 2004 Nov 9;101(45):16064-9. doi: 10.1073/pnas.0405041101. Epub 2004 Nov 1.
Proc Natl Acad Sci U S A. 2004.
PMID: 15520383
Free PMC article.
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