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Epigenetic reader SP140 loss of function drives Crohn's disease due to uncontrolled macrophage topoisomerases.
Cell. 2022 Aug 18;185(17):3232-3247.e18. doi: 10.1016/j.cell.2022.06.048. Epub 2022 Aug 10.
Cell. 2022.
PMID: 35952671
Free PMC article.
The Speckled Protein (SP) Family: Immunity's Chromatin Readers.
Fraschilla I, Jeffrey KL.
Fraschilla I, et al.
Trends Immunol. 2020 Jul;41(7):572-585. doi: 10.1016/j.it.2020.04.007. Epub 2020 May 5.
Trends Immunol. 2020.
PMID: 32386862
Free PMC article.
Review.
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One genome, many cell states: epigenetic control of innate immunity.
Fraschilla I, Amatullah H, Jeffrey KL.
Fraschilla I, et al.
Curr Opin Immunol. 2022 Apr;75:102173. doi: 10.1016/j.coi.2022.102173. Epub 2022 Apr 8.
Curr Opin Immunol. 2022.
PMID: 35405493
Free PMC article.
Review.
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Immune chromatin reader SP140 regulates microbiota and risk for inflammatory bowel disease.
Fraschilla I, Amatullah H, Rahman RU, Jeffrey KL.
Fraschilla I, et al.
Cell Host Microbe. 2022 Oct 12;30(10):1370-1381.e5. doi: 10.1016/j.chom.2022.08.018. Epub 2022 Sep 20.
Cell Host Microbe. 2022.
PMID: 36130593
Free PMC article.
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Viewing Siglecs through the lens of tumor immunology.
Fraschilla I, Pillai S.
Fraschilla I, et al.
Immunol Rev. 2017 Mar;276(1):178-191. doi: 10.1111/imr.12526.
Immunol Rev. 2017.
PMID: 28258691
Free PMC article.
Review.
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Biting the hand that feeds: Metabolic determinants of cell fate during infection.
Fraschilla I, Evavold CL.
Fraschilla I, et al.
Front Immunol. 2022 Oct 13;13:923024. doi: 10.3389/fimmu.2022.923024. eCollection 2022.
Front Immunol. 2022.
PMID: 36311735
Free PMC article.
Review.
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An engineered immunomodulatory IgG1 Fc suppresses autoimmune inflammation through pathways shared with i.v. immunoglobulin.
Sneed SL, Reese BB, Laureano AF, Ratnapriya S, Fraschilla I, Jeffrey KL, Coffey GP, Conley PB, Anthony RM.
Sneed SL, et al. Among authors: fraschilla i.
J Clin Invest. 2024 Feb 15;134(4):e172980. doi: 10.1172/JCI172980.
J Clin Invest. 2024.
PMID: 38357917
Free PMC article.
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New Member of the V1V2-Directed CAP256-VRC26 Lineage That Shows Increased Breadth and Exceptional Potency.
Doria-Rose NA, Bhiman JN, Roark RS, Schramm CA, Gorman J, Chuang GY, Pancera M, Cale EM, Ernandes MJ, Louder MK, Asokan M, Bailer RT, Druz A, Fraschilla IR, Garrett NJ, Jarosinski M, Lynch RM, McKee K, O'Dell S, Pegu A, Schmidt SD, Staupe RP, Sutton MS, Wang K, Wibmer CK, Haynes BF, Abdool-Karim S, Shapiro L, Kwong PD, Moore PL, Morris L, Mascola JR.
Doria-Rose NA, et al. Among authors: fraschilla ir.
J Virol. 2015 Oct 14;90(1):76-91. doi: 10.1128/JVI.01791-15. Print 2016 Jan 1.
J Virol. 2015.
PMID: 26468542
Free PMC article.
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