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Epigenetic reader SP140 loss of function drives Crohn's disease due to uncontrolled macrophage topoisomerases.
Amatullah H, Fraschilla I, Digumarthi S, Huang J, Adiliaghdam F, Bonilla G, Wong LP, Rivard ME, Beauchamp C, Mercier V, Goyette P, Sadreyev RI, Anthony RM, Rioux JD, Jeffrey KL. Amatullah H, et al. Among authors: jeffrey kl. Cell. 2022 Aug 18;185(17):3232-3247.e18. doi: 10.1016/j.cell.2022.06.048. Epub 2022 Aug 10. Cell. 2022. PMID: 35952671 Free PMC article.
Maintenance of macrophage transcriptional programs and intestinal homeostasis by epigenetic reader SP140.
Mehta S, Cronkite DA, Basavappa M, Saunders TL, Adiliaghdam F, Amatullah H, Morrison SA, Pagan JD, Anthony RM, Tonnerre P, Lauer GM, Lee JC, Digumarthi S, Pantano L, Ho Sui SJ, Ji F, Sadreyev R, Zhou C, Mullen AC, Kumar V, Li Y, Wijmenga C, Xavier RJ, Means TK, Jeffrey KL. Mehta S, et al. Among authors: jeffrey kl. Sci Immunol. 2017 Mar 3;2(9):eaag3160. doi: 10.1126/sciimmunol.aag3160. Epub 2017 Mar 3. Sci Immunol. 2017. PMID: 28783698 Free PMC article.
Exercise reduces inflammatory cell production and cardiovascular inflammation via instruction of hematopoietic progenitor cells.
Frodermann V, Rohde D, Courties G, Severe N, Schloss MJ, Amatullah H, McAlpine CS, Cremer S, Hoyer FF, Ji F, van Koeverden ID, Herisson F, Honold L, Masson GS, Zhang S, Grune J, Iwamoto Y, Schmidt SP, Wojtkiewicz GR, Lee IH, Gustafsson K, Pasterkamp G, de Jager SCA, Sadreyev RI, MacFadyen J, Libby P, Ridker P, Scadden DT, Naxerova K, Jeffrey KL, Swirski FK, Nahrendorf M. Frodermann V, et al. Among authors: jeffrey kl. Nat Med. 2019 Nov;25(11):1761-1771. doi: 10.1038/s41591-019-0633-x. Epub 2019 Nov 7. Nat Med. 2019. PMID: 31700184 Free PMC article.
A Requirement for Argonaute 4 in Mammalian Antiviral Defense.
Adiliaghdam F, Basavappa M, Saunders TL, Harjanto D, Prior JT, Cronkite DA, Papavasiliou N, Jeffrey KL. Adiliaghdam F, et al. Among authors: jeffrey kl. Cell Rep. 2020 Feb 11;30(6):1690-1701.e4. doi: 10.1016/j.celrep.2020.01.021. Cell Rep. 2020. PMID: 32049003 Free PMC article.
The Speckled Protein (SP) Family: Immunity's Chromatin Readers.
Fraschilla I, Jeffrey KL. Fraschilla I, et al. Among authors: jeffrey kl. Trends Immunol. 2020 Jul;41(7):572-585. doi: 10.1016/j.it.2020.04.007. Epub 2020 May 5. Trends Immunol. 2020. PMID: 32386862 Free PMC article. Review.
Illuminating the human virome in health and disease.
Adiliaghdam F, Jeffrey KL. Adiliaghdam F, et al. Among authors: jeffrey kl. Genome Med. 2020 Jul 27;12(1):66. doi: 10.1186/s13073-020-00766-x. Genome Med. 2020. PMID: 32718358 Free PMC article.
Epigenome-metabolome-microbiome axis in health and IBD.
Amatullah H, Jeffrey KL. Amatullah H, et al. Among authors: jeffrey kl. Curr Opin Microbiol. 2020 Aug;56:97-108. doi: 10.1016/j.mib.2020.08.005. Epub 2020 Sep 10. Curr Opin Microbiol. 2020. PMID: 32920333 Free PMC article. Review.
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